| Hemoglobin oxygen dissociation (P50) in bronchopulmonary dysplasia. | |
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MedLine Citation:
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PMID: 1690029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was devised to determine the P50 in infants with bronchopulmonary dysplasia (BPD). Other factors such as red blood cell 2,3-diphosphoglycerate (2,3-DPG) level proportions of adult (HbA) to fetal (HbF) hemoglobins which could affect P50 were also measured. Fourteen infants with clinical and radiological signs of BPD with a mean post-conceptional age of 42.2 +/- 4.7 weeks born at a mean gestational age of 29.3 +/- 2.0 weeks were evaluated. The percentage of HbF determined in 8 infants was 40.1 +/- 20.3% and the mean 2,3-DPG concentrations was 13.1 +/- 2.2 mumol/g Hb. The P50 was 25.1 +/- 2.7 mm Hg (range 18-29.5 mm Hg). When a HbO2 curve was established based on a large volume of blood consisting of adult blood and newborn cord blood mixed to attain a P50 of 25.1 mm Hg, the PaO2 at 90% O2 saturation was 52 mm Hg. Since there can be a wide range in HbO2 in infants with chronic BPD, pulse oximetry remains the most prudent method of monitoring oxygen therapy in BPD infants. |
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Authors:
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S Furfaro; J Prosmanne; H Bard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 57 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1990 |
Date Detail:
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Created Date: 1990-04-19 Completed Date: 1990-04-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 72-6 Citation Subset: IM |
Affiliation:
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Sainte-Justine Hospital, Department of Pediatrics, University of Montreal, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia
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physiopathology* Diphosphoglyceric Acids / analysis Fetal Hemoglobin / analysis Hemoglobin A / analysis Hemoglobins / analysis* Humans Infant, Newborn Infant, Premature* Oximetry Oxygen / blood* |
| Chemical | |
Reg. No./Substance:
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0/Diphosphoglyceric Acids; 0/Hemoglobins; 7782-44-7/Oxygen; 9034-51-9/Hemoglobin A; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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