Document Detail

Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography.
MedLine Citation:
PMID:  14562719     Owner:  NLM     Status:  MEDLINE    
This study examines the methodology of combining high-resolution information from magnetic resonance imaging into the reconstruction of near-infrared images of hemoglobin concentration and oxygen saturation. This type of hybrid imaging modality has the potential to provide noninvasive maps of hemoglobin concentration and oxygen saturation with relatively high spatial resolution with a fast time response. The study uses (i) tissue-simulating phantoms, as well as (ii) a rat cranial model, to test the method in two well-controlled situations. The phantom test demonstrates that better reconstruction accuracy can be achieved with the use of MRI-generated spatial regions in near-infrared reconstruction. The rat functional testing reveals that the technique can be applied to in vivo physiology, even in situations where the tissue is quite heterogenous. It also shows that the application of a priori structure in the finite element mesh as well as spatial constraints in the near-infrared image reconstruction, can significantly improve the quality of the resulting hemoglobin images.
Brian W Pogue; Haoqin Zhu; Casmair Nwaigwe; Troy O McBride; Ulf L Osterberg; Keith D Paulsen; Jeffery F Dunn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  530     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-24     Citation Subset:  IM    
Thayer School of Engineering, Dartmouth College, Lebanon, NH, USA.
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MeSH Terms
Hemoglobins / metabolism*
Oxygen / metabolism
Spectrophotometry, Infrared
Tomography / methods*
Grant Support
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

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