Document Detail

Hemoglobin heterogeneity under conditions of abnormal erythropoiesis.
MedLine Citation:
PMID:  12937674     Owner:  NLM     Status:  MEDLINE    
Experiments on rats showed that changes in the hemoglobin profile during hypoxia are determined by switching of erythropoiesis from the "basic" to "emergency" mode. The "basic" mode of erythropoiesis is typical of the mature organism under normal conditions. The "reserve" or "emergency" mode is realized in fetuses, senile animals, and during hypoxia. This mode is characterized by production of large erythrocytes with high content of fetal hemoglobin.
M N Sumin; A V Rezaikin; B G Yushkov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-08-25     Completed Date:  2004-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  563-5     Citation Subset:  IM    
Ekaterinburg Branch of the Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Ekaterinburg.
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MeSH Terms
Age Factors
Anoxia / metabolism*
Erythrocytes / chemistry,  metabolism
Erythropoiesis / physiology*
Hemoglobins / chemistry,  metabolism*
Protein Isoforms / metabolism*
Reg. No./Substance:
0/Hemoglobins; 0/Protein Isoforms

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