Document Detail

Hemoglobin and hematocrit at the end of hemodialysis: a better way to adjust erythropoietin dose?
MedLine Citation:
PMID:  20169384     Owner:  NLM     Status:  MEDLINE    
A severe disadvantage of administration of recombinant human erythropoietin to hemodialysis patients has been reported. A significant correlation has been shown with hemoglobin values determined online by use of the blood volume monitor (BVM) and by laboratory measurement. Online hemoglobin and hematocrit were measured by use of the BVM during hemodialysis session. Data were analyzed by t test and statistical significance was defined as a P of <0.05. Increases in the mean values of hemoglobin and hematocrit from 11.6 +/- 1.9 to 13.9 +/- 2.4 g/dL (17.4 +/- 7.1%, P = 0.02) and from 34.4 +/- 6.8 to 42 +/- 8.3% (20.6 +/- 8.8%, P = 0.022), respectively, were observed from the beginning to the end of dialysis. We hypothesize that a new strategy for adjusting erythropoietin dose may be based on hemoglobin and hematocrit values evaluated at the end of hemodialysis, when patients are no longer hypervolemic. Inadvertent high levels of hemoglobin could be one explanation why patients present higher rates of cardiovascular and access-related events, especially when monitored online by use of the BVM to achieve the dry weight.
Erika B Rangel; Maria Claudia Andreoli; Ana Cristina C Matos; Nadia K Guimar?es-Souza; Ana Cl?udia Mallet; Fabiana D Carneiro; Bento C Santos
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Publication Detail:
Type:  Journal Article     Date:  2010-02-19
Journal Detail:
Title:  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs     Volume:  13     ISSN:  1619-0904     ISO Abbreviation:  J Artif Organs     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815648     Medline TA:  J Artif Organs     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Division of Nephrology, Universidade Federal de S?o Paulo, S?o Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Blood Volume
Erythropoietin, Recombinant / administration & dosage*
Hematocrit / methods*
Hemoglobins / analysis*
Middle Aged
Patient Selection
Renal Dialysis / methods*
Reg. No./Substance:
0/Erythropoietin, Recombinant; 0/Hemoglobins

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