| Hemoglobin and hematocrit at the end of hemodialysis: a better way to adjust erythropoietin dose? | |
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MedLine Citation:
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PMID: 20169384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A severe disadvantage of administration of recombinant human erythropoietin to hemodialysis patients has been reported. A significant correlation has been shown with hemoglobin values determined online by use of the blood volume monitor (BVM) and by laboratory measurement. Online hemoglobin and hematocrit were measured by use of the BVM during hemodialysis session. Data were analyzed by t test and statistical significance was defined as a P of <0.05. Increases in the mean values of hemoglobin and hematocrit from 11.6 +/- 1.9 to 13.9 +/- 2.4 g/dL (17.4 +/- 7.1%, P = 0.02) and from 34.4 +/- 6.8 to 42 +/- 8.3% (20.6 +/- 8.8%, P = 0.022), respectively, were observed from the beginning to the end of dialysis. We hypothesize that a new strategy for adjusting erythropoietin dose may be based on hemoglobin and hematocrit values evaluated at the end of hemodialysis, when patients are no longer hypervolemic. Inadvertent high levels of hemoglobin could be one explanation why patients present higher rates of cardiovascular and access-related events, especially when monitored online by use of the BVM to achieve the dry weight. |
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Authors:
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Erika B Rangel; Maria Claudia Andreoli; Ana Cristina C Matos; Nadia K Guimar?es-Souza; Ana Cl?udia Mallet; Fabiana D Carneiro; Bento C Santos |
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Publication Detail:
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Type: Journal Article Date: 2010-02-19 |
Journal Detail:
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Title: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs Volume: 13 ISSN: 1619-0904 ISO Abbreviation: J Artif Organs Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815648 Medline TA: J Artif Organs Country: Japan |
Other Details:
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Languages: eng Pagination: 63-6 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Universidade Federal de S?o Paulo, S?o Paulo, Brazil. erikabr@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Volume Erythropoietin, Recombinant / administration & dosage* Female Hematocrit / methods* Hemoglobins / analysis* Humans Male Middle Aged Patient Selection Renal Dialysis / methods* |
| Chemical | |
Reg. No./Substance:
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0/Erythropoietin, Recombinant; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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