| Hemoglobin-based oxygen carrier distribution inside vascular wall and arterial pressure evolution: is there a relationship? | |
| | |
MedLine Citation:
|
PMID: 15818035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hemoglobin-based oxygen carriers (HBOC), like dextran-benzene-tetracarboxylate-hemoglobin (Dex-BTC-Hb), which are present at high concentrations in plasma disturb arterial pressure and induce hypertension. To study if the increase of mean arterial pressure (MAP) is due to the presence of cell-free hemoglobin (Hb) inside abdominal aortic wall, we followed on a model of 50% isovolemic exchange transfusion (IET) in anesthetized guinea pigs, the kinetic of Dex-BTC-Hb distribution inside abdominal aortic wall and we investigated the relationship between arterial pressure modifications and modified Hb distribution. The administration of Dex-BTC-Hb induced instantaneously an increase of MAP that reached its maximum (53% of hypertension from baseline) at 17 min after the end of the IET and was maintained maximally up to 30 min. A significantly decrease of MAP (45% of hypertension from baseline) was observed after 60 min and the baseline level was recovered at 180 min. The investigation of tissue at 17 min by confocal microscopy showed the presence of free Hb in or upon endothelial cells (EC) in intima and in vasa vasorum. At 180 min, the free Hb was found in or upon EC and inside all abdominal aortic wall meanwhile MAP recovered its basal value. These results suggest for the first time that Hb in intima seems to induce the hypertension observed upon IET but can not sustain it even if Hb stayed present in intima and in abdominal aortic wall. |
| | |
Authors:
|
Y Smani; Béatrice Faivre; Sandra Audonnet-Blaise; P Labrude; C Vigneron |
Related Documents
:
|
2096645 - Response time of mitochondrial oxygen consumption following stepwise changes in cardiac... 22170175 - How implicit motives and everyday self-regulatory abilities shape cardiovascular risk i... 18064525 - Subcutaneous oxygen pressure in spontaneously breathing lean and obese volunteers: a pi... 3621495 - Correlation of force-length area with oxygen consumption in ferret papillary muscle. 1391265 - Lung mechanics (frc and static pressure-volume diagram) after endotracheal surfactant i... 6493455 - Influence of histamine and prostaglandin on desensitization to neurotensin in rat blood... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 37 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 2005 Jan-Feb |
Date Detail:
|
Created Date: 2005-04-08 Completed Date: 2005-07-12 Revised Date: 2006-11-30 |
Medline Journal Info:
|
Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
|
Department of Hematology and Physiology, EA 3452 Faculty of Pharmacy, University Henri Poincaré-Nancy I, Nancy, France. Younes.Smani@pharma.uhp-nancy.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta, Abdominal / metabolism, physiology* Blood Pressure / drug effects* Blood Substitutes / pharmacokinetics*, pharmacology* Dextrans / pharmacokinetics*, pharmacology* Endothelial Cells / metabolism Guinea Pigs Hematocrit Hemoglobins / pharmacokinetics*, pharmacology* Kinetics Male Microscopy, Confocal Time Factors Tissue Distribution Tunica Intima / metabolism Vasa Vasorum / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Blood Substitutes; 0/Hemoglobins; 0/hemoglobin-dextran 10-benzene-tetracarboxylate; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Withdrawal of warfarin prior to a surgical procedure: time to follow the guidelines?
Next Document: Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardi...