| Hemoglobin-based Oxygen Carrier (HBOC-201) and Escalating Doses of Recombinant Factor VIIa (rFVIIa) as a Novel Pre-hospital Resuscitation Fluid in a Swine Model of Severe Uncontrolled Hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 20645681 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 μg/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 μg/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 μg/kg group. Verification in a large, well-powered study is indicated. |
| | |
Authors:
|
Anke Scultetus; Francoise Arnaud; Lewis Kaplan; Aryeh Shander; Nora Philbin; Jennifer Rice; Richard McCarron; Daniel Freilich |
Publication Detail:
|
Type: Journal Article Date: 2010-07-20 |
Journal Detail:
|
Title: Artificial cells, blood substitutes, and immobilization biotechnology Volume: 39 ISSN: 1532-4184 ISO Abbreviation: Artif Cells Blood Substit Immobil Biotechnol Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9431307 Medline TA: Artif Cells Blood Substit Immobil Biotechnol Country: England |
Other Details:
|
Languages: eng Pagination: 59-68 Citation Subset: IM |
Affiliation:
|
Naval Medical Research Center, Operational and Undersea Medicine Directorate, NeuroTrauma Department, Silver Spring, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left ventricular hypertrophy detection and body mass index in essential hypertension.
Next Document: Novel GABA(B) receptor positive modulators: a patent survey.