| Hemoglobin Shelby [beta 131(H9) Gln----Lys] a correction to the structure of hemoglobin Deaconess and hemoglobin Leslie. | |
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MedLine Citation:
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PMID: 6526653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemoglobin Shelby, detected in two unrelated black families, has an electrophoretic mobility like Hb F on cellulose acetate (pH 8.4) and a mobility between Hbs S and C on citrate agar (pH 6.2). Globin chain analysis in acid and alkaline buffers revealed an abnormal chain migrating between beta A and beta S. Tests for unstable hemoglobins were positive. Hematologic data on both families indicated carriers have mild anemia. The variant showed a slightly lower affinity for oxygen with normal cooperativity and Bohr effect, and its reactions with 2,3-diphosphoglycerate and inositol hexaphosphate were similar to those of Hb A. Sequence analysis indicated the substitution of lysine for glutamine at position 131 in the beta-chain. In a previous report (1) we described a variant, Hb Deaconess, in which this residue was deleted. On reexamination of the data, we find that Hb Deaconess is identical to Hb Shelby. |
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Authors:
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W F Moo-Penn; M H Johnson; J E McGuffey; D L Jue |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Hemoglobin Volume: 8 ISSN: 0363-0269 ISO Abbreviation: Hemoglobin Publication Date: 1984 |
Date Detail:
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Created Date: 1985-04-10 Completed Date: 1985-04-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7705865 Medline TA: Hemoglobin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 583-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amino Acid Sequence Amino Acids / analysis* Blood Protein Electrophoresis Chromatography, High Pressure Liquid Female Hemoglobins, Abnormal / analysis* Humans Infant Male |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Hemoglobins, Abnormal; 56690-69-8/hemoglobin Shelby |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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