Document Detail

Hemoglobin Linkoping [beta 36 (C2) Pro----Thr] in a large Finnish family from Astoria, Oregon, USA.
MedLine Citation:
PMID:  3096913     Owner:  NLM     Status:  MEDLINE    
Eleven members of a large Finnish family from Astoria, Oregon were studied because of an erythrocytosis. No abnormality was detected by the usual hemoglobin electrophoretic tests, but an abnormal variant was separated by reverse phase HPLC. All of the affected individuals have an increased oxygen affinity with a P50 for whole blood at 37 degrees C averaging 18 torr. Fifty percent of their hemoglobin was found to have a threonyl residue in place of the normal prolyl residue at position 36 (C2) of the beta globin chain. This abnormality is identical to Hb Linkoping which was recently reported in a Finnish man living in Sweden.
R T Jones; C Head; M F Shih; D T Shih; B Dana; M B Jones; R D Koler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hemoglobin     Volume:  10     ISSN:  0363-0269     ISO Abbreviation:  Hemoglobin     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-02     Completed Date:  1987-01-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7705865     Medline TA:  Hemoglobin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  455-67     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Finland / ethnology
Hemoglobins, Abnormal / analysis*,  genetics
Proline / physiology
Threonine / physiology
Grant Support
Reg. No./Substance:
0/Hemoglobins, Abnormal; 147-85-3/Proline; 72-19-5/Threonine; 89700-67-4/hemoglobin Linkoeping

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