Document Detail


Hemoglobin F in primary myelofibrosis and in myelodysplasia.
MedLine Citation:
PMID:  12974718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our study investigated two groups of adult patients with established diagnoses of primary myelofibrosis (21 patients) and myelodysplastic syndromes (MDS) (21 patients). The objective was to assess fetal hemoglobin (HbF) concentration and to investigate correlations with organomegaly and extramedullary hematopoiesis and with the level of anemia and blood transfusion requirement. In all patients, the diagnosis was confirmed by histopathological examination. Patients with myelofibrosis were investigated by ferrokinetics using 59Fe. The percentage of marrow sideroblasts was assessed in patients with refractory anemia with ringed sideroblasts. Increased values of HbF were found to occur both in patients with myelofibrosis and with MDS, although a higher incidence and higher concentrations were evident in patients with myelofibrosis. Statistically significant increases in HbF concentration were found when there was accompanying organomegaly, as compared to patients without this feature. The average HbF concentration in both groups of patients under study was twice as high in cases with as in those without marrow fibrosis. The difference was statistically significant. Increased HbF levels appear to correlate with extramedullary hematopoiesis. HbF concentration did not correlate with the level of anemia or with requirement for blood transfusion.
Authors:
E Mendek-Czajkowska; M Słomkowski; E Zdebska; U Mokras; A Sikorska; R Maryniak; T Górski; J Zych-Mordzińska; B Bielecka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  25     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-16     Completed Date:  2004-06-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
Affiliation:
Clinic of Hematology, Institute of Hematology and Blood Transfusion, Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Sideroblastic / complications
Erythropoiesis
Female
Fetal Hemoglobin / analysis*
Humans
Male
Middle Aged
Myelodysplastic Syndromes / diagnosis*,  pathology
Primary Myelofibrosis / diagnosis*,  pathology
Chemical
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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