Document Detail

Hemoglobin F in myelodysplastic syndrome.
MedLine Citation:
PMID:  9619730     Owner:  NLM     Status:  MEDLINE    
Reactivation of fetal hemoglobin synthesis in adulthood can be seen in hematological disorders affecting the erythropoietic system. The objective of the present study was to evaluate the incidence and prognostic significance of increased hemoglobin F in patients with myelodysplastic syndrome. Hemoglobin F concentrations and Ggamma/Ggamma + A gamma-globin chain ratios were determined in 26 patients with primary myelodysplastic syndrome. Median age of the patients was 65 years; all FAB subtypes were included. Increased hemoglobin F concentration of up to 20% of total hemoglobin (normal: below 2%) was seen in 16 patients; ten patients had normal values. There was a significant relation between hemoglobin F concentration and the course of disease, e.g., 12 of the 16 patients with elevated hemoglobin F survived at least 1 year after the examination, in contrast to only three of the ten patients with normal hemoglobin F (p < 0.025). All of six patients with hemoglobin F above 5% survived at least 1 year. There was no significant difference in the hemoglobin F concentration between patients with and without cytogenetic anomalies. The Ggamma/Ggamma + A gamma-globin chain ratio was slightly elevated in all patients, with a weak correlation to the degree of hemoglobin F elevation. The values were not of additional prognostic significance. The data of the present study suggest that the hemoglobin F concentration may be a prognostic parameter in myelodysplastic syndrome; increased hemoglobin F concentration may indicate a better prognosis.
D Reinhardt; D Haase; C Schoch; S Wollenweber; E Hinkelmann; W v Heyden; G Lentini; B Wörmann; W Schröter; A Pekrun
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hematology     Volume:  76     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-06-25     Completed Date:  1998-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Department of Pediatrics, University of Göttingen, Germany.
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MeSH Terms
Aged, 80 and over
Biological Markers
Fetal Hemoglobin / analysis*
Middle Aged
Myelodysplastic Syndromes / blood*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 9034-63-3/Fetal Hemoglobin

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