Document Detail

Hemoglobin A2 levels in healthy persons, sickle cell disease, sickle cell trait, and beta-thalassemia by capillary isoelectric focusing.
MedLine Citation:
PMID:  8980373     Owner:  NLM     Status:  MEDLINE    
Simultaneously measuring major and minor hemoglobin (Hb) variants by capillary isoelective focusing, we obtained HbA2 intervals in healthy volunteers (n = 412) (reference value) and patients with HbS or beta-thalassemia. We classified normal HbA2 reference intervals into three age groups: 5 months or younger (1.2% +/- 1.5%), 6 months to 1 year (2.2% +/- 0.9%), and 1 year or older (2.4% +/- 0.9%). These intervals were comparable to those used with other methods. Patients 1 year of age or older with HbS had significantly higher HbA2 levels (sickle cell trait, 2.9% +/- 0.9%; sickle cell anemia, 2.8% +/- 1.0%; P < .05). Although reference HbA2 intervals overlapped those in patients with HbS, no overlap in HbA2 levels was noted between these groups and patients with beta-thalassemia (observed range, 4.3% to 7.5%). The higher than normal HbA2 interval in patients with HbS must be considered before a diagnosis of sickle cell trait or sickle cell disease with beta-thalassemia is made.
R D Craver; J G Abermanis; R P Warrier; D L Ode; J M Hempe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  107     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-91     Citation Subset:  AIM; IM    
Department of Pathology, Louisiana State University, New Orleans, USA.
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MeSH Terms
Anemia, Sickle Cell / blood*
Child, Preschool
Hemoglobin A2 / analysis*
Hemoglobin, Sickle / analysis
Isoelectric Focusing / methods*
Reference Values
Sickle Cell Trait / blood*
beta-Thalassemia / blood*
Reg. No./Substance:
0/Hemoglobin, Sickle; 9034-53-1/Hemoglobin A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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