| Hemoglobin A1c above Threshold Level is Associated with Decreased β-Cell Function in Overweight Latino Youth. | |
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MedLine Citation:
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PMID: 22137671 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether a hemoglobin A1c (HbA1c)-identified prediabetic state (HbA1c ≥6.0%-6.4%) is associated with decreased insulin sensitivity (SI) and β-cell dysfunction, known factors in the pathogenesis of type 2 diabetes, in an overweight pediatric population. STUDY DESIGN: A total of 206 healthy overweight Latino adolescents (124 males and 82 females; mean age, 13.1±2.0 years) were divided into 2 groups: lower risk (n=179), with HbA1c <6.0%, and higher risk (n=27), with HbA1c 6.0%-6.4%. Measurements included HbA1c, oral glucose tolerance testing, fasting and 2-hour glucose and insulin, SI, acute insulin response, and disposition index (an index of β-cell function) by the frequently sampled intravenous glucose tolerance test with minimal modeling. Body fat was determined by dual-energy X-ray absorptiometry. RESULTS: Compared with the lower risk group, the higher risk group had 21% lower SI (1.21±0.06 vs 1.54±0.13; P<.05), 30% lower acute insulin response (928±102 vs 1342±56; P<.01), and a 31% lower disposition index (1390±146 vs 2023±83; P=.001) after adjusting for age and total percent body fat. CONCLUSION: These data provide clear evidence of greater impairment of β-cell function in overweight Latino children with HbA1c 6.0%-6.4%, and thereby support the adoption of the International Expert Committee's HbA1c-determined definition of high-risk state for overweight children at risk for type 2 diabetes. |
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Authors:
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Claudia M Toledo-Corral; Lisa G Vargas; Michael I Goran; Marc J Weigensberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-3 |
Journal Detail:
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Title: The Journal of pediatrics Volume: - ISSN: 1097-6833 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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