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Hemoglobin A1c is Associated with Carotid Intima-Media Thickness in a Chinese Population.
MedLine Citation:
PMID:  21668461     Owner:  NLM     Status:  Publisher    
Background  The association between hemoglobin A1c (HbA1c) levels and subclinical atherosclerosis in carotid arteries in Chinese populations is unknown. Aim, design and methods  The objective of this study was to investigate this relationship and evaluate the ability of HbA1c levels to predict carotid atherosclerosis in a Chinese population. This was a cross-sectional study, which included 541 subjects without known diabetes (Taiwan Lifestyle Study). About 67 (9.2%) subjects were newly diagnosed with diabetes during the study. Carotid intima-media thickness (IMT) and the presence of carotid plaques were determined by ultrasonography. Results  The HbA1c level in all subjects was positively correlated with carotid IMT (beta = 0.018, p = 0.03) after being adjusted for age, gender, smoking, low-density lipoprotein cholesterol level, hypertension, and body mass index. HbA1c level was higher in subjects with plaques in carotid arteries (p = 0.01). There was a positive and linear relationship between HbA1c levels and the probability of having plaques, thickened carotid IMT, or both (p for all comparisons, <0.05). The ability of HbA1c levels to predict thickened carotid IMT or the presence of plaques was only modest (the optimal cutoff of HbA1c level (5.7%) was determined from the receiver operating characteristic [ROC] curve [sensitivity = 67%, specificity = 61%] and the area under the ROC curve [0.666]). Conclusions  Thus, HbA1c level is associated with subclinical atherosclerosis in carotid arteries in a Chinese population. The relationship is linear without an inflection point. However, HbA1c criterion is not a useful marker for the identification of subclinical atherosclerosis.
Chi Sheng Hung; Po-Chu Lee; Hung-Yuan Li; Wen-Ya Ma; Mao-Shin Lin; Jung-Nan Wei; Shyang-Rong Shih; Cyue-Huei Hua; Lee-Ming Chuang; Ming-Fong Chen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-10
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan Department of Surgery and Traumatology, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Division of Endocrinology, Department of Internal Medicine, Cardinal Tien Hospital, Xindian 231, Medical School, Catholic Fu Jen University, Taipei, Taiwan Graduate Institute of Clinical Medicine, Medical College, National Taiwan University, Taipei, Taiwan Chia Nan University of Pharmacy and Science, Tainan, Taiwan Division of Clinical Pathology' National Taiwan University Hospital Yun-Lin Branch, Yun-Lin Taiwan Graduate Institute of Preventive Medicine, National Taiwan University School of Public Health, Taipei, Taiwan.
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