Document Detail

Hemofiltration modifies complement activation after extracorporeal circulation in infants.
MedLine Citation:
PMID:  8267479     Owner:  NLM     Status:  MEDLINE    
Complement and fibrinolytic factors were measured in 9 infants undergoing hemofiltration immediately after cardiopulmonary bypass in an attempt to reduce activation of these systems. Plasma levels of C3a, C5a, and terminal complement complexes increased during bypass by 460%, 85%, and 745%. Plasma levels were reduced after hemofiltration in 8 of the 9 infants, and C3a and C5a fractions were recovered in the ultrafiltrate. The observed activation of the fibrinolytic system seemed to be unaltered by hemofiltration. Fibrinolytic factors were not filtered. Our study shows that increased concentrations of complement factors in the plasma after bypass in infants may be reduced by hemofiltration.
S Andreasson; S Göthberg; H Berggren; A Bengtsson; E Eriksson; B Risberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  56     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-01-25     Completed Date:  1994-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1515-7     Citation Subset:  AIM; IM    
Department of Pediatric Anesthesia, East Hospital, Gothenburg, Sweden.
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MeSH Terms
Complement Activation / physiology*
Complement C3a / metabolism
Complement C5a / metabolism
Extracorporeal Circulation*
Fibrinolysis / physiology
Heart Defects, Congenital / surgery*
Reg. No./Substance:
80295-42-7/Complement C3a; 80295-54-1/Complement C5a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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