| Hemofiltration modifies complement activation after extracorporeal circulation in infants. | |
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MedLine Citation:
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PMID: 8267479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complement and fibrinolytic factors were measured in 9 infants undergoing hemofiltration immediately after cardiopulmonary bypass in an attempt to reduce activation of these systems. Plasma levels of C3a, C5a, and terminal complement complexes increased during bypass by 460%, 85%, and 745%. Plasma levels were reduced after hemofiltration in 8 of the 9 infants, and C3a and C5a fractions were recovered in the ultrafiltrate. The observed activation of the fibrinolytic system seemed to be unaltered by hemofiltration. Fibrinolytic factors were not filtered. Our study shows that increased concentrations of complement factors in the plasma after bypass in infants may be reduced by hemofiltration. |
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Authors:
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S Andreasson; S Göthberg; H Berggren; A Bengtsson; E Eriksson; B Risberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 56 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-01-25 Completed Date: 1994-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1515-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatric Anesthesia, East Hospital, Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement Activation
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physiology* Complement C3a / metabolism Complement C5a / metabolism Extracorporeal Circulation* Fibrinolysis / physiology Heart Defects, Congenital / surgery* Hemofiltration* Humans Infant |
| Chemical | |
Reg. No./Substance:
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80295-42-7/Complement C3a; 80295-54-1/Complement C5a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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