Document Detail

Hemodynamics of revascularization for iliofemoral venous occlusion: a short-term canine model.
MedLine Citation:
PMID:  3184315     Owner:  NLM     Status:  MEDLINE    
A short-term canine model of lower extremity venous hypertension was created to study the hemodynamics of crossfemoral venous bypass grafts (CFB). Specifically, the hemodynamic effects of bypass conduit diameter and adjunctive arteriovenous fistulas (AVFs) were investigated. Unilateral hind limb venous hypertension was produced by iliofemoral venous ligation in six groups of five greyhounds each. Group I had venous ligation alone. CFBs were constructed in the remaining five groups: group II, 3 mm bypass conduit alone; group III, 3 mm bypass plus sequential AVF; group IV, 3 mm bypass plus caudad AVF; group V, 3 mm bypass plus cephalad AVF; group VI, 6 mm bypass conduit alone. Venous hypertension was significantly reduced by CFB (group II, p less than 0.025; group VI, p less than 0.001); increasing the diameter of the bypass conduit from 3 to 6 mm produced significantly greater graft flow (p less than 0.05), while completely relieving venous hypertension. Addition of adjunctive AVFs significantly augmented graft flow (p less than 0.001) but tended to aggravate ipsilateral venous hypertension (group III, p less than 0.01; group IV increase, NSS; group V, p less than 0.001). During the 4 hours of pressure monitoring, venous hypertension diminished significantly (p less than 0.05) with the sequential AVF but not with the other AVF. We conclude that (1) AVFs may be required for adequate graft flow if a small-diameter (3 mm) bypass conduit is used to relieve venous hypertension; (2) adjunctive AVFs aggravate venous hypertension; (3) sequential AVFs seem to be the most hemodynamically efficacious; (4) AVFs may not be necessary if a large, isodiametric (6 mm) conduit is used.
S G Lalka; C Cosentino; J M Malone; R L Reinert; V M Bernhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  8     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-02     Completed Date:  1988-12-02     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-9     Citation Subset:  IM    
Section of Vascular Surgery, University of Arizona, Tucson.
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MeSH Terms
Anastomosis, Surgical
Arteriovenous Shunt, Surgical
Carotid Arteries / transplantation
Disease Models, Animal
Femoral Vein / physiopathology*,  surgery
Iliac Vein / physiopathology*,  surgery
Jugular Veins / transplantation
Venous Insufficiency / physiopathology*
Venous Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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