| Hemodynamics and left ventricular mass regression following implantation of the Toronto SPV stentless porcine valve. | |
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MedLine Citation:
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PMID: 9832097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stentless tissue valves may provide more favorable hemodynamics than conventional stented valves. Hemodynamic findings from a large multicenter trial have not been previously reported. The present report describes the hemodynamic findings from a multinational, multicenter study after implantation of the Toronto SPV valve. A total of 577 patients underwent aortic valve replacement with the Toronto SPV valve at 12 sites in 3 countries. Echocardiograms were recorded in the early postoperative period, 3 to 6 months after surgery, 1 year after surgery, and yearly thereafter, with follow-up to 3 years. Gradients decreased and effective orifice area increased in the months after surgery. One year after surgery, mean gradient for valve sizes 20 to 22, 23, 25, 27, and 29 mm was 7.3 +/- 4.4, 7.4 +/- 4.5, 6.1 +/- 3.3, 4.9 +/- 2.4, and 4.0 +/- 2.1 mm Hg, respectively; effective orifice area was 1.3 +/- 0.7, 1.5 +/- 0.5, 1.7 +/- 0.4, 2.0 +/- 0.4, and 2.4 +/- 0.6 cm2, respectively. There was a very low prevalence of significant aortic regurgitation at all time periods. There was significant left ventricular (LV) mass regression between the early and 3- to 6-month periods and between the 3- to 6-month and 1-year postoperative periods. The Toronto SPV valve has an excellent hemodynamic profile supported by significant regression of LV hypertrophy in the year after implantation. Data through 3 years demonstrates maintenance of low gradients and freedom from significant aortic regurgitation. |
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Authors:
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D S Bach; T David; M Yacoub; J Pepper; B Goldman; J Wood; E Verrier; M Petracek; V Aldrete; M Rosenbloom; H Azar; H Rakowski |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 82 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-14 Completed Date: 1998-12-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1214-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA. dbach@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Valve Aortic Valve Insufficiency / etiology, ultrasonography Bioprosthesis* Cohort Studies Female Heart Valve Prosthesis* Heart Valve Prosthesis Implantation Hemodynamics* Humans Hypertrophy, Left Ventricular* / surgery, ultrasonography Male Middle Aged Observer Variation Postoperative Complications / ultrasonography Postoperative Period Prevalence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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