| Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling. | |
| | |
MedLine Citation:
|
PMID: 17012350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice. |
| | |
Authors:
|
Akiva Feintuch; Permyos Ruengsakulrach; Amy Lin; Ji Zhang; Yu-Qing Zhou; Jonathon Bishop; Lorinda Davidson; David Courtman; F Stuart Foster; David A Steinman; R Mark Henkelman; C Ross Ethier |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-29 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 292 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-02-08 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H884-92 Citation Subset: IM |
Affiliation:
|
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta, Thoracic / physiology*, ultrasonography* Atherosclerosis / physiopathology Blood Flow Velocity Brachiocephalic Trunk / physiology, ultrasonography Carotid Artery, Common / physiology, ultrasonography Computer Simulation Disease Models, Animal Finite Element Analysis Humans Laser-Doppler Flowmetry* Magnetic Resonance Imaging* Mice Mice, Inbred C57BL Models, Cardiovascular* Pulsatile Flow Regional Blood Flow Shear Strength Species Specificity Stress, Mechanical Subclavian Artery / physiology, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in isolated, per...
Next Document: TRPC3 channels colocalize with Na+/Ca2+ exchanger and Na+ pump in axial component of transverse-axia...