Document Detail

Hemodynamics of the cerebral arteries of infants with periventricular leukomalacia.
MedLine Citation:
PMID:  16396853     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study investigated the developmental changes in blood flow in each cerebral artery among infants with and without periventricular leukomalacia (PVL), to elucidate the time of onset of PVL. METHODS: Eight of 67 low birth weight infants were diagnosed through ultrasonography as having PVL with cyst formation. The mean cerebral blood flow velocities (CBFVs) in the anterior cerebral artery, middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), internal carotid arteries (ICAs), and basilar artery were measured with Doppler ultrasonography at postnatal days 0, 1, 2, 3, 4, 5, 7, 10, 14, 21, 28, 42, 56, and 70. Four of 8 infants with cyst formation and 1 of 59 infants without cyst formation developed cerebral palsy. RESULTS: The mean CBFVs of infants with PVL were significantly lower in the anterior cerebral artery (days 14-70), the right MCA (days 14-70), the left MCA (days 14-70), the right PCA (days 7-70), the left PCA (days 5-70), the right ICA (days 7-70), the left ICA (days 7-70), and the basilar artery (days 14 and 28-70). The CBFVs in all arteries were also lower among those with PVL than among intact infants on day 0. The CBFVs increased postnatally in the PCAs of infants with intact brains, whereas they remained unchanged after day 14 or 21 among infants with PVL. There was a significant difference in the prevalence of cerebral palsy between the 2 groups. CONCLUSIONS: We suggest that the total cerebral blood supply is decreased in cases of cystic PVL and that this reduction occurs just after birth, in a defined sequence, in the cerebral arteries. We conclude that the insult resulting in PVL might occur close to the time of birth.
Sumio Fukuda; Takenori Kato; Hiroki Kakita; Yasumasa Yamada; Mohamed Hamed Hussein; Ineko Kato; Satoshi Suzuki; Hajime Togari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  117     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-06     Completed Date:  2006-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  AIM; IM    
Department of Pediatrics, Neonatology, and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
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MeSH Terms
Blood Flow Velocity*
Cerebral Arteries* / ultrasonography
Cerebrovascular Circulation*
Infant, Low Birth Weight
Infant, Newborn
Leukomalacia, Periventricular / diagnosis,  physiopathology*,  ultrasonography
Ultrasonography, Doppler, Transcranial
Comment In:
Pediatrics. 2006 Jan;117(1):212-3   [PMID:  16396880 ]

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