| Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy. | |
| | |
MedLine Citation:
|
PMID: 20305886 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate hemodynamics and bispectral index (BIS) in bitches anesthetized with ketamine and midazolam in combination with dexmedetomidine or medetomidine and submitted to ovariohysterectomy. METHODS: Twenty bitches pretreated with levomedetomidine and buprenorphine were anesthetized with 5 mg*kg(-1) ketamine and 0.2 mg*kg(-1) midazolam i.v. Continuous infusion of 0.4 mg*kg(-1)*h(-1) midazolam and 20 mg*kg(-1)*h(-1) ketamine was initiated in combination with DEX (n=10): 20 microg*kg(-1)*h(-1) dexmedetomidine or MED (n=10): 30 microg*kg(-1)*h(-1) medetomidine over 30 minutes. A pharmacokinetic study provided dexmedetomidine plasma concentration, set to be 3.0 ng*mL(-1). RESULTS: BIS decreased in both groups (P<0.05), but it was lower in DEX (P<0.05) as compared to MED. No differences were found in hemodynamic parameters (heart rate, systolic, diastolic and mean arterial pressure) between groups (P>0.05), but heart rate decreased in both groups, as compared to control values (P<0.05). Respiratory rate decreased (P<0.05) and expired end tidal CO(2) increased progressively (P<0.05) and similarly in both groups. Anesthetic recovery period was similar between groups (P<0.05) with no adverse effects. CONCLUSION: Continuous administration of dexmedetomidine with calculated plasma concentration equal to 3 ng.mL-1 in combination with midazolam and ketamine provides suitable anesthesia for spay surgery in bitches, hemodynamic stability and calm awakening with no adverse effects. |
| | |
Authors:
|
Fernando do Carmo Silva; Eduardo Hatschbach; Yuri Karaccas de Carvalho; Bruno Watanabe Minto; Flávio Massone; Paulo do Nascimento Junior |
Related Documents
:
|
562086 - Circulatory response to laryngoscopy and tracheal intubation with or without prior orop... 11217886 - Increase in pulse transit time to the foot after epidural anaesthesia treatment. 9646256 - Stability of cardiodynamic and some blood parameters in the baboon following intravenou... 2863916 - Haemodynamic stability during anaesthesia induction and sternotomy in patients with isc... 7187276 - Microvascular architecture of the mechanically induced hydrosalpinx in the rabbit. 12974426 - Isolated lipid abnormalities in rural and urban normotensive and hypertensive north-wes... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 25 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
|
Languages: eng Pagination: 181-9 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Botucatú Medical School, UNESP, Botucatú-SP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of copaiba balsam on Walker 256 carcinoma inoculated into the vagina and uterine cervix o...
Next Document: Dartos flap coverage of the neourethra following repair for primary hypospadias, reoperative hypospa...