Document Detail

Hemodynamics of Cerebral Aneurysms.
MedLine Citation:
PMID:  19784385     Owner:  NLM     Status:  Publisher    
The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.
Daniel M Sforza; Christopher M Putman; Juan Raul Cebral
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Publication Detail:
Journal Detail:
Title:  Annual review of fluid mechanics     Volume:  41     ISSN:  0066-4189     ISO Abbreviation:  Annu Rev Fluid Mech     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101165244     Medline TA:  Annu Rev Fluid Mech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  91-107     Citation Subset:  -    
Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030.
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Grant Support
R01 NS059063-01//NINDS NIH HHS

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