Document Detail

Hemodynamic and visual function effects of oral nifedipine in patients with normal-tension glaucoma.
MedLine Citation:
PMID:  9439355     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate ocular hemodynamic and visual function changes in patients with normal-tension glaucoma after treatment with a calcium channel blocker (nifedipine). METHODS: In 21 patients with normal-tension glaucoma, color Doppler imaging of the ophthalmic, central retinal, and short posterior ciliary arteries was carried out after a 4-week washout of prior drug treatment and again after 6 months of treatment with nifedipine (30 mg per day). Visual field sensitivity, spatial contrast sensitivity, and intraocular pressure were also recorded. RESULTS: Three subjects experienced intolerable side effects from the drug and were removed from the study. In two other patients, visual function was substantially reduced after 4 months of treatment; nifedipine was discontinued. In the remaining 16 subjects, mean intraocular pressure, retrobulbar hemodynamics, visual field mean sensitivity, and contrast sensitivity at 3, 12, and 18 cycles per degree (cpd), respectively, were unchanged after nifedipine treatment. Contrast sensitivity at 6 cpd, however, improved after drug treatment (P = .004). Individuals with the greatest improvements in contrast sensitivity at 6 cpd showed the largest increases in ophthalmic arterial peak systolic velocity (r = .57; P = .02) and end-diastolic velocity (r = .65; P = .001). CONCLUSION: Nifedipine fails to provide uniform visual function or retrobulbar hemodynamic responses in patients with normal-tension glaucoma. Those patients who do show improved visual function also show improved indices of retrobulbar perfusion.
A Harris; D W Evans; L B Cantor; B Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  124     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-28     Completed Date:  1998-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-302     Citation Subset:  AIM; IM    
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
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MeSH Terms
Administration, Oral
Calcium Channel Blockers / administration & dosage,  adverse effects,  therapeutic use*
Ciliary Arteries / physiology,  ultrasonography
Contrast Sensitivity / physiology*
Eye / blood supply*
Glaucoma / drug therapy*,  physiopathology
Hemodynamics / physiology*
Intraocular Pressure
Middle Aged
Nifedipine / administration & dosage,  adverse effects,  therapeutic use*
Ophthalmic Artery / physiology,  ultrasonography
Retinal Artery / physiology,  ultrasonography
Ultrasonography, Doppler, Color
Visual Fields / physiology*
Grant Support
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine

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