Document Detail


Hemodynamic and visual function effects of oral nifedipine in patients with normal-tension glaucoma.
MedLine Citation:
PMID:  9439355     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate ocular hemodynamic and visual function changes in patients with normal-tension glaucoma after treatment with a calcium channel blocker (nifedipine). METHODS: In 21 patients with normal-tension glaucoma, color Doppler imaging of the ophthalmic, central retinal, and short posterior ciliary arteries was carried out after a 4-week washout of prior drug treatment and again after 6 months of treatment with nifedipine (30 mg per day). Visual field sensitivity, spatial contrast sensitivity, and intraocular pressure were also recorded. RESULTS: Three subjects experienced intolerable side effects from the drug and were removed from the study. In two other patients, visual function was substantially reduced after 4 months of treatment; nifedipine was discontinued. In the remaining 16 subjects, mean intraocular pressure, retrobulbar hemodynamics, visual field mean sensitivity, and contrast sensitivity at 3, 12, and 18 cycles per degree (cpd), respectively, were unchanged after nifedipine treatment. Contrast sensitivity at 6 cpd, however, improved after drug treatment (P = .004). Individuals with the greatest improvements in contrast sensitivity at 6 cpd showed the largest increases in ophthalmic arterial peak systolic velocity (r = .57; P = .02) and end-diastolic velocity (r = .65; P = .001). CONCLUSION: Nifedipine fails to provide uniform visual function or retrobulbar hemodynamic responses in patients with normal-tension glaucoma. Those patients who do show improved visual function also show improved indices of retrobulbar perfusion.
Authors:
A Harris; D W Evans; L B Cantor; B Martin
Related Documents :
3103795 - Effect of nifedipine on the lower esophageal sphincter pressure in chagasic patients.
20091275 - Antihypertensive role of glossopharyngeal nerve stimulation by nifedipine using as calc...
11104295 - Evaluation of treatment efficacy of raynaud phenomenon by digital blood pressure respon...
6681035 - Haemodynamic effects of nifedipine in essential hypertension at rest and during exercise.
7692155 - Effects of d-nebivolol and l-nebivolol on left ventricular systolic and diastolic funct...
2627695 - Hypotensive properties of antibodies directed against an endogenous pressor peptide iso...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  124     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-28     Completed Date:  1998-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  296-302     Citation Subset:  AIM; IM    
Affiliation:
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis 46202, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Calcium Channel Blockers / administration & dosage,  adverse effects,  therapeutic use*
Ciliary Arteries / physiology,  ultrasonography
Contrast Sensitivity / physiology*
Eye / blood supply*
Female
Glaucoma / drug therapy*,  physiopathology
Hemodynamics / physiology*
Humans
Intraocular Pressure
Male
Middle Aged
Nifedipine / administration & dosage,  adverse effects,  therapeutic use*
Ophthalmic Artery / physiology,  ultrasonography
Retinal Artery / physiology,  ultrasonography
Ultrasonography, Doppler, Color
Visual Fields / physiology*
Grant Support
ID/Acronym/Agency:
EY 10801/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The relationship between progression of visual field defects and retrobulbar circulation in patients...
Next Document:  Topical mitomycin C for the treatment of conjunctival and corneal epithelial dysplasia and neoplasia...