| Hemodynamic, ventilatory and metabolic effects of light isometric exercise in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 3392326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light isometric exercise, such as lifting or carrying loads that require 25% of a maximal voluntary contraction, is frequently reported to cause dyspnea in patients with heart failure. The pathophysiologic mechanisms responsible for the appearance of this symptom, however, are unknown. Accordingly, hemodynamic, metabolic and ventilatory responses to 6 min of light isometric forearm exercise were examined and compared in 20 patients with chronic heart failure and abnormal ejection fraction (24 +/- 9%) and 17 normal individuals. In contrast to findings in normal volunteers, exercise cardiac index did not increase whereas exercising forearm and mixed venous lactate concentrations increased (p less than 0.05) above levels at rest in patients with heart failure; at 90 s of recovery, blood lactate concentration remained elevated (p less than 0.05). The venous lactate concentration of the nonexercising arm, unlike that of the exercising forearm, was not altered. Oxygen uptake, carbon dioxide production and minute ventilation increased similarly in patients and normal subjects during exercise, but only in patients did each increase further (p less than 0.05) during recovery. Thus, in patients with heart failure, light isometric forearm exercise represents an anaerobic contraction with lactate production. The subsequent increase in carbon dioxide production leads to a disproportionate increase in minute ventilation and oxygen uptake during recovery that may be perceived as breathlessness. |
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Authors:
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H K Reddy; K T Weber; J S Janicki; P A McElroy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 12 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-08-25 Completed Date: 1988-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 353-8 Citation Subset: AIM; IM; S |
Affiliation:
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Division of Cardiology, Michael Reese Hospital, University of Chicago, Illinois 60616. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiac Output Female Heart Failure / blood, physiopathology* Heart Rate Hemodynamics* Humans Isometric Contraction* Lactates / blood Male Middle Aged Muscle Contraction* Oxygen / blood Oxygen Consumption Pulmonary Wedge Pressure Respiration* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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