Document Detail

Hemodynamic and vascular response to resistance exercise with L-arginine.
MedLine Citation:
PMID:  19276857     Owner:  NLM     Status:  MEDLINE    
PURPOSE: L-arginine, the precursor to nitric oxide (NO), has been shown to improve endothelial function in patients with endothelial dysfunction. Resistance exercise has been shown to increase arterial stiffness acutely with no definitive cause. It is possible that a reduction in NO bioavailability is responsible for this. The purpose of this study was to examine the effect of acute L-arginine supplementation and resistance exercise on arterial function. METHODS: Eighteen (N = 18) young men (24.2 +/- 0.7 yr) volunteered for this study. In a crossover design, subjects underwent body composition testing, 1-repetition maximum testing for the bench press and the biceps curls and performed two acute bouts of resistance exercise in which they consumed either placebo or 7 g L-arginine before each resistance exercise bout. Anthropometric measures, augmentation index (AIx), arterial stiffness, and forearm blood flow (FBF) were assessed before and after each treatment condition. RESULTS: There were significant (P < 0.05) time effects after the resistance exercise; there was a reduction in brachial stiffness (P = 0.0001), an increase in central aortic stiffness (P = 0.004), an increase in AIx (P = 0.023), an increase in FBF (P = 0.000), and an increase in arm circumference (P = 0.0001) after exercise. CONCLUSIONS: The increase in central arterial stiffness and wave reflection was not attenuated by acute supplementation with L-arginine; furthermore, blood flow was not augmented with supplementation. On the basis of these data, l-arginine does not appear to change the hemodynamic and vascular responses to resistance exercise.
Christopher A Fahs; Kevin S Heffernan; Bo Fernhall
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  41     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  773-9     Citation Subset:  IM; S    
Department of Kinesiology and Community Health, Exercise and Cardiovascular Research Laboratory, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.
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MeSH Terms
Arginine / administration & dosage*,  pharmacology
Cross-Over Studies
Double-Blind Method
Hemodynamics / drug effects*,  physiology
Nitric Oxide / metabolism
Vascular Resistance / drug effects*,  physiology
Weight Lifting / physiology*
Young Adult
Reg. No./Substance:
10102-43-9/Nitric Oxide; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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