| Hemodynamic responses to obstructive respiratory events during sleep are augmented in women with preeclampsia. | |
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MedLine Citation:
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PMID: 11724205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preeclampsia is the most common disease of pregnancy, occurring in up to 10% of the pregnant population. The cause of the disease is as yet undetermined; however, most of the clinical effects are commonly attributed to damage to the endothelial layer, leading to increased pressor activity of all the maternal blood vessels. Therefore, we suspected that if obstructive sleep apnea (OSA) coexisted with preeclampsia in pregnancy, the hemodynamic effects of the OSA would be markedly potentiated. To test this hypothesis, we performed full sleep studies and overnight beat-to-beat blood pressure (BP) monitoring. The control patient group included 10 pregnant women with OSA and no evidence of hypertensive disease either before or during their current pregnancy. The test group included 10 women with preeclampsia and coexisting OSA. The pressor responses to obstructive respiratory events during sleep were enhanced in preeclamptic patients compared with control OSA patients (21+/-2/12+/-1 mm Hg and 38+/-5/25+/-4 mm Hg above baseline in control OSA and preeclamptic OSA patients, respectively, P = .005/.005). In contrast, there was no difference in heart rate responses between the two groups of subjects (34+/-5 beats/min and 49+/-13 beats/min above baseline in control and preeclamptic patient groups, respectively, P = .326). We suggest that the augmented pressor responses in preeclamptic women occur as a result of maternal endothelial damage induced by the preeclampsia disease process. These findings may have important implications in the management of preeclamptic patients. |
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Authors:
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N Edwards; D M Blyton; T T Kirjavainen; C E Sullivan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 14 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-28 Completed Date: 2002-03-06 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 1090-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, The University of Sydney, Australia. ne@blackburn.med.usyd.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure* Case-Control Studies Endothelium, Vascular / physiopathology Female Gestational Age Heart Rate* Humans Oxygen / blood Polysomnography Pre-Eclampsia / blood, complications*, physiopathology* Pregnancy Risk Factors Severity of Illness Index Sleep Apnea, Obstructive / blood, complications*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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