Document Detail

Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure.
MedLine Citation:
PMID:  2908715     Owner:  NLM     Status:  MEDLINE    
The effects of prazosin, clonidine, and indoramin on central and regional hemodynamic parameters and left ventricular performance were analyzed in a congestive heart failure population to compare the pharmacodynamic responses to different levels of alpha-adrenergic interruption in this condition. The sympathetic nervous system is blocked at the peripheral alpha1-receptor by prazosin, at central nervous system alpha-receptor sites (via alpha-adrenoceptor agonism) by clonidine, and at peripheral and central sites by indoramin. Prazosin and indoramin produced reductions in total systemic and pulmonary vascular resistances, mean systemic and pulmonary artery pressures, and pulmonary capillary wedge pressure with little change in heart rate. Both agents selectively increased hepatic blood flow. Clonidine also decreased pulmonary artery pressure and vascular resistance, but evoked negative inotropic and chronotropic activity and did not alter regional blood flow. In contrast to prazosin, indoramin and clonidine did not augment cardiac output or stroke volume. In the setting of congestive heart failure, the central and regional hemodynamic effects and the responses in left ventricular performance vary considerably depending on the site of alpha-adrenergic interruption.
A P Good; D V Unverferth; C V Leier
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  1     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1991-05-01     Completed Date:  1991-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
Department of Medicine, Ohio State University, Columbus 43210.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*,  therapeutic use
Clonidine / pharmacology,  therapeutic use
Extremities / blood supply
Heart Failure / drug therapy*,  physiopathology
Hemodynamics / drug effects*
Indoramin / pharmacology,  therapeutic use
Liver / blood supply
Liver Circulation / drug effects
Middle Aged
Prazosin / pharmacology,  therapeutic use
Regional Blood Flow / drug effects
Stroke Volume / drug effects
Vascular Resistance / drug effects
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 19216-56-9/Prazosin; 26844-12-2/Indoramin; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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