| Hemodynamic response to respiratory challenges in panic disorder. | |
| | |
MedLine Citation:
|
PMID: 9483471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study compares the hemodynamic response to panic disorder subjects with that of normal controls during respiratory challenges. Panic patients meeting DSM-IIIR criteria for panic disorder and normal controls were challenged with room air hyperventilation, 5% CO2 breathing, and 7% CO2 breathing. Measurements of pulse and blood pressure were taken at resting baseline and before and at the end of each respiratory challenge. Panic attack to each challenge was determined by using raters blinded to subject diagnosis and each subject's self-rating of panic. Significantly larger systolic and diastolic blood pressure increases were found in patients who panicked with room air hyperventilation than nonpanicking patients or normal controls. No significant blood pressure differences were found with 7% or 5% CO2 challenges, but higher pulse rates were found in the patient group. It may be possible that panic with room air hyperventilation causes a significant increase in systolic and diastolic blood pressure, or that a subgroup of panic disorder patients has a hyperactive vascular response to hypocapnia. These patients panic with room air hyperventilation and develop greater vasoconstriction and/or increased blood pressure response. |
| | |
Authors:
|
J M Martinez; J D Coplan; S T Browne; R Goetz; L A Welkowitz; L A Papp; D F Klein; J M Gorman |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of psychosomatic research Volume: 44 ISSN: 0022-3999 ISO Abbreviation: J Psychosom Res Publication Date: 1998 Jan |
Date Detail:
|
Created Date: 1998-04-15 Completed Date: 1998-04-15 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376333 Medline TA: J Psychosom Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 153-61 Citation Subset: IM |
Affiliation:
|
Biological Studies Unit, New York State Psychiatric Institute, Columbia University, New York 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Adult Blood Pressure / drug effects, physiology Carbon Dioxide / administration & dosage, diagnostic use*, pharmacology Female Hemodynamics / drug effects, physiology* Humans Hyperventilation* / complications Hypocapnia / etiology Intervention Studies Male Middle Aged Panic Disorder / chemically induced, diagnosis*, etiology |
| Grant Support | |
ID/Acronym/Agency:
|
MH-00416/MH/NIMH NIH HHS; MH-00858/MH/NIMH NIH HHS; MH-30960/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autonomic balance revisited: panic anxiety and heart rate variability.
Next Document: Neurobiology of panic disorder.