Document Detail

Hemodynamic and pulmonary changes after drainage of significant pleural effusions in critically ill, mechanically ventilated surgical patients.
MedLine Citation:
PMID:  15625448     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Our purpose was to study the effects of drainage of significant pleural effusions in mechanically ventilated patients in a surgical intensive care unit. METHODS: Twenty-two ventilated patients in the surgical intensive care unit of a tertiary care center over a 12-month period who developed a pleural effusion large enough to require drainage were studied prospectively. All patients underwent serial portable chest radiography in the upright or semiupright position; the radiographs were reviewed by a radiology attending. Pleural effusions were classified as small, moderate, or large. Moderate or larger effusions were drained using an 8- to 12-Fr pigtail catheter inserted at the bedside under ultrasound guidance. Hemodynamic and pulmonary parameters were collected before and after the fluid was drained. Parameters studied included those outlined in the physiologic profile and included measured and calculated physiologic variables, arterial blood gas measurements, and Svo2 measurements. Ventilator settings before and after were also recorded. RESULTS: Average initial pleural effusion drainage was 1,262 +/- 762 mL (range, 300-2,980 mL). Nine of the 22 patients had effusions drained from both the right and left chest. Blood pressure, systemic vascular resistance, Po2, Pco2, Svo2, Fio2, peak airway pressure, and spontaneous volume did not change significantly. Pulmonary capillary wedge pressure decreased (17.4 +/- 6.0 before, 13.6 +/- 4.4 after; p < 0.01), central venous pressure decreased (14.2 +/- 5.2 before, 11.5 +/- 4.4 after; p < 0.02), and pulmonary arteriovenous shunt decreased (26.7 +/- 15.1 before, 21.0 +/- 7.8 after; p < 0.04). Oxygen delivery increased (579.7 +/- 214.7 before, 662.8 +/- 263.3 after; p < 0.01) and oxygen consumption increased (146.3 +/- 61.6 before, 175.2 +/- 73.8 after; p < 0.01). Respiratory rate also decreased (19.4 +/- 6.5 before, 15.5 +/- 6.3 after; p < 0.05). There were no complications from the placement of the pigtail catheters. CONCLUSION: Drainage of pleural effusions results in increased oxygen delivery and oxygen consumption coinciding with a decrease in pulmonary capillary wedge pressure. The pulmonary arteriovenous shunt decreased, implying an increase in functional residual capacity and improved oxygenation. Further study is needed to determine whether these changes lead to an improved patient outcome (i.e., reduction in length of stay, ventilator days, or mortality).
Syed H Ahmed; Steven P Ouzounian; Stephen Dirusso; Thomas Sullivan; John Savino; Louis Del Guercio
Related Documents :
3300118 - Volume substitution and treatment with prostaglandin e1 in a porcine model of endotoxae...
3551968 - Acute effects of ibopamine hydrochloride on hemodynamics, plasma catecholamine levels, ...
7664848 - Pathogenesis of high-altitude pulmonary oedema: direct evidence of stress failure of pu...
6814298 - Hemodynamic effects of intravenous nitroglycerin: importance of the delivery system.
7883288 - Cardiovascular responses to phenylephrine and sodium nitroprusside during acute coronar...
8182128 - Pressure promotes dna synthesis in rat cultured vascular smooth muscle cells.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  57     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-30     Completed Date:  2006-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1184-8     Citation Subset:  AIM; IM    
Department of Surgery, New York Medical College, Valhalla, New York, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Functional Residual Capacity
Middle Aged
Oxygen / metabolism
Pleural Effusion / radiography,  therapy*
Pulmonary Wedge Pressure
Respiration, Artificial
Respiratory Physiological Phenomena
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intrapleural tissue plasminogen activator for complicated pleural effusions.
Next Document:  The tip of the iceberg for child abuse: the critical roles of the pediatric trauma service and its r...