Document Detail

Hemodynamic profile of amiodarone during acute and long-term administration in patients with ventricular dysfunction.
MedLine Citation:
PMID:  2102806     Owner:  NLM     Status:  MEDLINE    
One of the potential adverse effects of anti-arrhythmic agents is an impairment of cardiac function as a result of their intrinsic negative inotropic properties. Amiodarone, in animals, also induces dose-related negative inotropic effects, in addition to coronary and systemic vasodilatation and slowing of the heart. Likewise, in most human studies, intravenous amiodarone gives rise to early systemic and coronary vasodilatation, followed by a reduction in contractility. Depending on the relative impact of these opposing effects on the left ventricle, the changes in heart rate, cardiac output and left ventricular filling pressure are variable. Particularly in patients with pre-existing ventricular dysfunction, cardiac pump function is impaired further when relatively high dosages of amiodarone are used without its solvent Tween 80. In contrast, fast bolus administrations, eg. 5 mg/kg amiodarone in 5 minutes, result in an improvement of cardiac output, albeit at the expense of an increase in left ventricular filling pressure. The latter observation suggests that intravenous amiodarone should be given with caution in patients with heart failure and elevated left ventricular filling pressures. When given by mouth, amiodarone does not have significant hemodynamic effects, other than a moderate reduction in heart rate and, occasionally, in diastolic blood pressure. Cardiac pump function is not affected, even in patients with ventricular dysfunction or heart failure, in whom chronic oral administration of the drug is well tolerated.
W J Remme; D C van Hoogenhuyze
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardioscience     Volume:  1     ISSN:  1015-5007     ISO Abbreviation:  Cardioscience     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-10-03     Completed Date:  1991-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9014943     Medline TA:  Cardioscience     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
Cardiovascular Research Foundation Sticares, Rotterdam, The Netherlands.
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MeSH Terms
Amiodarone / administration & dosage,  adverse effects,  therapeutic use*
Arrhythmias, Cardiac / drug therapy*
Dose-Response Relationship, Drug
Heart Failure / physiopathology
Hemodynamics / drug effects*
Myocardial Contraction / drug effects
Time Factors
Ventricular Function / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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