Document Detail


Hemodynamic performance of fresh and calcified aortic valve prostheses in critical low stroke volume.
MedLine Citation:
PMID:  18592929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM OF THE STUDY: Heart failure is common following aortic valve replacement, and optimal prosthesis function is crucial in this critical clinical setting. The study aim was to investigate the hemodynamic performance and leaflet kinematics of fresh and calcified biological aortic valves in a simulated low stroke volume situation. METHODS: Edwards Perimount Magna (PM) and Medtronic Mosaic Ultra (MU) valves were investigated in an artificial circulation system (130 beats/min, stroke volume 19 ml), and the results compared to normal output (70 beats/min, stroke volume 70 ml). Leaflet kinematics were visualized using a high-speed camera. All valves were exposed to a calcifying solution for six weeks. RESULTS: In the low- and normal-output situation, the PM valve initially demonstrated lower pressure gradients compared to the MU valve (low output 2.4 +/- 0.16 versus 3.4 +/- 0.19 mmHg), but showed a significantly higher closing volume (up to 19% of stroke volume) leading to an increased total energy loss. Regurgitation for the PM valve was explained by progressively longer opening and closing times. The PM valve calcified faster and more severely, leading to increasing gradients and closure volume. CONCLUSION: In the low stroke volume situation pericardial valves demonstrated superior systolic performance, but inferior diastolic performance, leading to a higher total energy loss compared to porcine valves. This finding may have clinical relevance in heart-failure patients.
Authors:
Omer Dzemali; Farhad Bakhtiary; Ulrich Steinseiffer; Christof Schmitz; Brigit Glasmacher; Anton Moritz; Peter Kleine
Related Documents :
24613189 - Ex vivo proof-of-concept of end-to-end scaffold-enhanced laser-assisted vascular anast...
463929 - Dysautonomia in mitral valve prolapse.
17252209 - Remotely adjustable check-valves with an electrochemical release mechanism for implanta...
15335429 - Effect of vagus nerve stimulator magnet on programmable shunt settings.
2776159 - Quantitative assessment of aortic regurgitation by colour flow doppler in an open chest...
3339169 - Determination of left-sided pressure gradients by utilizing doppler aortic and mitral r...
6728169 - Accurate intracranial pressure monitoring: technical note.
1297849 - The effects of ventricular end-diastolic and systolic pressures on action potential and...
18979189 - Intrascleral drug delivery to the eye using hollow microneedles.
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  17     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Johann Wolfgang Goethe University Hospital, Frankfurt/Main, Germany. dzemali@em.uni-frankfurt.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Valve / physiology*
Biomechanics
Calcinosis / physiopathology*
Cardiomyopathies / physiopathology*
Diastole
Heart Valve Prosthesis*
Models, Animal
Models, Cardiovascular
Stroke Volume / physiology*
Swine
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of gap width on viscous stresses within the leakage across a bileaflet valve pivot.
Next Document:  Ex-vivo characterization of three Björk-Shiley Delrin heart valves.