Document Detail

Hemodynamic parameters and renal blood flow following stimulation of renal tubular transport processes by treatment with thyroid hormones.
MedLine Citation:
PMID:  3444849     Owner:  NLM     Status:  MEDLINE    
In adult rats, renal excretion of p-aminohippurate (PAH) can be stimulated by repeated administration of thyroid hormones. Data on renal cortical slices show clearly that a stimulation of active, carrier-mediated tubular transport processes is the most important cause. In vivo experiments also show an influence of treatment with thyroid hormones on various hemodynamic parameters. The diminution of vascular resistance in cortical and medullary regions of the kidney might contribute to the increased PAH excretion in thyroid hormone-treated rats.
H Bräunlich; F Jahn; J Bartha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  42     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-05-04     Completed Date:  1988-05-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  846-8     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Budapest.
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MeSH Terms
Biological Transport / drug effects
Hemodynamics / drug effects*
Kidney Cortex / drug effects,  metabolism
Kidney Tubules / drug effects*,  metabolism
Rats, Inbred Strains
Renal Circulation / drug effects*
Thyroid Hormones / pharmacology*
Thyroxine / pharmacology
Triiodothyronine / pharmacology
p-Aminohippuric Acid / pharmacokinetics
Reg. No./Substance:
0/Thyroid Hormones; 61-78-9/p-Aminohippuric Acid; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

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