| Hemodynamic and neural mechanisms of acute neurogenic hypertension in the rat. | |
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MedLine Citation:
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PMID: 6507647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experiments were performed to test the hypothesis that acute hypertension caused by aortic baroreceptor deafferentation (ABD) is the result of sympathetic vasoconstriction. Cardiac output (CO), mean arterial pressure (MAP), and total peripheral resistance (TPR) were measured before and after ABD in anesthetized and conscious rats. The role of the sympathetic nervous system in acute ABD-induced hypertension was evaluated by examining the ability of adrenalectomy, adrenal demedullation, guanethidine or combined adrenal demedullation, and guanethidine pretreatment to prevent, and total autonomic blockade to reverse, ABD-induced hypertension. CO did not change significantly after ABD at any time, whereas MAP and TPR increased significantly (P less than 0.05). Only combined adrenal demedullation and guanethidine pretreatment prevented ABD-induced hypertension, and autonomic blockade normalized MAP in ABD rats. Normalization of blood pressure was the result of a decreased TPR. It is concluded that acute ABD-induced hypertension results from vasoconstriction caused by neurally released and/or circulating catecholamines. |
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Authors:
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A H Werber; W J Bryan; G D Fink |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 247 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-01-24 Completed Date: 1985-01-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H991-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adrenal Medulla / physiology Adrenalectomy Animals Atropine / pharmacology Autonomic Nerve Block Biomechanics Blood Pressure / drug effects Cardiac Output Denervation Guanethidine / pharmacology Hemodynamics* Hypertension / physiopathology*, prevention & control Male Nervous System / physiopathology* Phentolamine / pharmacology Pressoreceptors / physiology* Propranolol / pharmacology Rats Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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50-60-2/Phentolamine; 51-55-8/Atropine; 525-66-6/Propranolol; 55-65-2/Guanethidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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