Document Detail

Hemodynamic monitoring in pulmonary arterial hypertension.
MedLine Citation:
PMID:  21510728     Owner:  NLM     Status:  MEDLINE    
Pulmonary arterial hypertension (PAH) is a progressive disease that results in elevation of the pulmonary artery pressure and ultimately development of right ventricular failure. Baseline and periodic invasive hemodynamics via right heart catheterization are generally obtained in order to characterize and follow the extent of hemodynamic derangement, response to therapy, and as an end point in clinical trials of novel therapy. Therapy for PAH is steadily evolving, with considerable uncertainty regarding optimal dosing and comparative efficacy of the available therapeutic agents. Ambulatory hemodynamic monitoring techniques are under development that facilitate availability of hemodynamic parameters ad libitum. Such techniques provide novel insights into cardiovascular pathophysiology during activity and may prove to be useful in allowing early detection of hemodynamic changes between clinic visits. Hemodynamics obtained from implantable monitors have been used during PAH medical therapy in pilot studies and could be used as an end point in clinical trials of PAH therapy. Future efforts should focus on proof of clinical utility of implantable monitoring and refinement of cardiac output estimation by pressure waveform analysis.
Robert P Frantz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of respiratory medicine     Volume:  5     ISSN:  1747-6356     ISO Abbreviation:  Expert Rev Respir Med     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-08-16     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  101278196     Medline TA:  Expert Rev Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Division of Cardiovascular Diseases and Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure* / drug effects
Blood Pressure Determination* / instrumentation,  methods
Blood Pressure Monitoring, Ambulatory
Blood Pressure Monitors
Cardiac Output
Equipment Design
Exercise Test
Heart Catheterization
Hypertension, Pulmonary* / diagnosis,  drug therapy,  physiopathology
Myocardial Contraction
Predictive Value of Tests
Severity of Illness Index
Signal Processing, Computer-Assisted
Time Factors
Treatment Outcome
Ventricular Function, Right
Reg. No./Substance:
0/Antihypertensive Agents

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