| Hemodynamic monitoring in pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 21510728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is a progressive disease that results in elevation of the pulmonary artery pressure and ultimately development of right ventricular failure. Baseline and periodic invasive hemodynamics via right heart catheterization are generally obtained in order to characterize and follow the extent of hemodynamic derangement, response to therapy, and as an end point in clinical trials of novel therapy. Therapy for PAH is steadily evolving, with considerable uncertainty regarding optimal dosing and comparative efficacy of the available therapeutic agents. Ambulatory hemodynamic monitoring techniques are under development that facilitate availability of hemodynamic parameters ad libitum. Such techniques provide novel insights into cardiovascular pathophysiology during activity and may prove to be useful in allowing early detection of hemodynamic changes between clinic visits. Hemodynamics obtained from implantable monitors have been used during PAH medical therapy in pilot studies and could be used as an end point in clinical trials of PAH therapy. Future efforts should focus on proof of clinical utility of implantable monitoring and refinement of cardiac output estimation by pressure waveform analysis. |
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Authors:
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Robert P Frantz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of respiratory medicine Volume: 5 ISSN: 1747-6356 ISO Abbreviation: Expert Rev Respir Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-16 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 101278196 Medline TA: Expert Rev Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Diseases and Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. frantz.robert@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Blood Pressure* / drug effects Blood Pressure Determination* / instrumentation, methods Blood Pressure Monitoring, Ambulatory Blood Pressure Monitors Cardiac Output Equipment Design Exercise Test Heart Catheterization Humans Hypertension, Pulmonary* / diagnosis, drug therapy, physiopathology Myocardial Contraction Predictive Value of Tests Severity of Illness Index Signal Processing, Computer-Assisted Telemetry Time Factors Treatment Outcome Ventricular Function, Right |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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