Document Detail

Hemodynamic and metabolic profile in offspring of malignant hypertensive parents.
MedLine Citation:
PMID:  11566942     Owner:  NLM     Status:  MEDLINE    
Malignant hypertension is a serious form of arterial hypertension in which the physiopathological mechanisms include increased activity of the sympathetic nervous system, renin angiotensin system, and endothelium dysfunction. Family history of hypertension is an important predictive factor for hypertension and is associated with metabolic and hemodynamic abnormalities. Studies of these abnormalities in malignant hypertensive offspring have not yet been published. Therefore, we studied 42 offspring of malignant hypertensive parents (OMH group: age, 22+/-7 years; 23 male subjects; 27 white) and 35 offspring of normotensive parents (ONT group: age, 21+/-4 years; 23 male subjects; 25 white). All subjects had blood pressure <140/90 mm Hg. We evaluated body mass index; office blood pressure; 24-hour ambulatory and continuous beat-to-beat blood pressure monitoring (Finapres); biochemical analysis, including total cholesterol and fractions, triglycerides, glucose, and insulin; and hormonal analysis, including plasma renin activity, aldosterone, and catecholamines. The subjects were also submitted to cold pressure test and handgrip measurements. The body mass index was significantly higher in the OMH group (24+/-5 kg/m(2)) than in the ONT group (22+/-4 kg/m(2)). The OMH group showed significantly higher blood pressure and heart rate in office and Finapres measurements (P<0.05). In 24-hour ambulatory monitoring, the OMH group presented higher 24-hour blood pressure and heart rate, higher blood pressure during the night, and higher heart rate variability during the day compared with those of the ONT group. They also presented lower HDL cholesterol, higher levels of plasma insulin and norepinephrine, and higher insulin-to-glucose ratio (P<0.05) than the ONT group. There were no differences in the other biochemical parameters measured. In conclusion, OMH subjects show early hemodynamic, neurohumoral, and metabolic alterations that are typical of hypertensive metabolic syndrome.
H F Lopes; L A Bortolotto; C Szlejf; C S Kamitsuji; E M Krieger
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  38     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-21     Completed Date:  2001-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  616-20     Citation Subset:  IM    
Unidade de Hipertensão-Heart Institute, School of Medicine, São Paulo University, São Paulo, Brasil.
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MeSH Terms
Aldosterone / blood
Blood Glucose / metabolism
Blood Pressure / physiology
Cholesterol / blood
Family Health
Heart Rate / physiology
Hemodynamics / physiology*
Hypertension / blood,  genetics,  physiopathology*
Insulin / blood
Potassium / blood
Renin / blood
Sodium / blood
Stress, Physiological / physiopathology
Triglycerides / blood
Uric Acid / blood
Reg. No./Substance:
0/Blood Glucose; 0/Triglycerides; 11061-68-0/Insulin; 52-39-1/Aldosterone; 57-88-5/Cholesterol; 69-93-2/Uric Acid; 7440-09-7/Potassium; 7440-23-5/Sodium; EC

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