| Hemodynamic mechanisms underlying cerebral aneurysm pathogenesis. | |
| | |
MedLine Citation:
|
PMID: 21917457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Intracranial aneurysms and associated subarachnoid hemorrhage (SAH) are predominant cerebrovascular disorders that present a significant public health risk through high rates of morbidity and mortality. Unruptured aneurysms that become large enough compress cerebral tissue and manifest various neurological signs. But the largest danger presented by these cerebrovascular lesions is from the increased likelihood that the vessel will rupture, causing a SAH, a condition that creates higher risk of cerebral ischemia through reduced cerebral blood flow and vasospasm. The specific pathophysiological mechanisms that cause these lesions are not fully understood. The current literature focuses on understanding the effects of and links between hemodynamic forces, vascular remodeling and inflammation, and genetics in aneurysm formation, development, and rupture. The present study represents a survey of the complete hemodynamic pathogenesis of aneurysmal SAH detailing the many factors and their connections that contribute to the pathophysiology of this disorder. |
| | |
Authors:
|
David L Penn; Ricardo J Komotar; E Sander Connolly |
Related Documents
:
|
21789697 - Carotid artery stenting trials: conduct, results, critique, and current recommendations. 18581007 - Ruptured superficial femoral artery aneurysm treated by simple ligation. 19418007 - Anatomic variations of popliteal artery that may be a reason for entrapment. 20375917 - Retrograde femoral nailing: computed tomography angiogram demonstrates no relative safe... 1393457 - Monitoring and cerebral protection during carotid endarterectomy. 22837867 - Massive dilatation of the pulmonary artery in association with pulmonic stenosis and pu... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-12 |
Journal Detail:
|
Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: - ISSN: 1532-2653 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Neurological Surgery, Columbia University, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Test-retest reliability and descriptive statistics of geometric measurements based on plantar pressu...
Next Document: Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no ...