| Hemodynamic interactions of propofol and dantrolene in chronically instrumented dogs. | |
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MedLine Citation:
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PMID: 12707135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hemodynamic interaction of dantrolene, a specific drug for malignant hyperthermia, and propofol which appears to be safe in malignant hyperthermia-susceptible patients, has not been investigated. We performed this study to examine the hemodynamic actions of dantrolene at a therapeutic dose during propofol anesthesia. Ten dogs were chronically instrumented for the measurements of systemic and coronary hemodynamics. The dogs were assigned to receive propofol with vehicle or dantrolene in a random manner on separate experimental days. Propofol significantly decreased mean arterial blood pressure, left ventricular systolic and end-diastolic pressure, the maximal rate of increase in left ventricular pressure, and left ventricular regional segment shortening. Coronary blood flow (CBF) was unchanged but coronary vascular resistance (CVR) decreased. Dantrolene reversed the decrease in mean arterial blood pressure and left ventricular systolic pressure caused by propofol, and significantly increased heart rate. However, left ventricular end-diastolic pressure, cardiac output, maximal rate of increase in left ventricular pressure, and segment shortening were unchanged. CBF was significantly increased with a decrease in CVR. These results suggest that dantrolene reverses the hypotensive action produced by propofol and causes an increase in CBF with a decrease in CVR, but does not significantly change the negative inotropic effects. Thus, dantrolene exerts favorable hemodynamic effects during propofol anesthesia. IMPLICATIONS: Our study suggests that dantrolene reverses the hypotensive action produced by propofol and causes an increase in coronary blood flow with a decrease in coronary vascular resistance, but does not significantly change the negative inotropic effects. |
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Authors:
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Sungsam Cho; Shiping Zhang; Hiroyuki Ureshino; Tetsuya Hara; Shiro Tomiyasu; Koji Sumikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 96 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-22 Completed Date: 2003-05-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 1369-73, table of contents Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Nagasaki University School of Medicine, Japan. chos@net.nagasaki-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous
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pharmacology* Animals Coronary Circulation / drug effects Dantrolene / pharmacology* Dogs Drug Interactions Female Heart Rate / drug effects Hemodynamics / drug effects* Male Muscle Relaxants, Central / pharmacology* Propofol / pharmacology* Stroke Volume / drug effects Vascular Resistance Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Muscle Relaxants, Central; 2078-54-8/Propofol; 7261-97-4/Dantrolene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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