Document Detail


Hemodynamic influence of altered distal salt delivery on glomerular microcirculation.
MedLine Citation:
PMID:  6957667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current notion that tubuloglomerular feedback-mediated regulation of GFR involves selective changes in afferent arteriolar vasomotor tone stems from the familiar finding that manipulation of distal salt delivery alters glomerular capillary hydraulic pressure (PGC). Stop-flow technique, which has been used for this PGC measurement, however, has recently been shown to fail to provide a reliable estimate of true PGC. In the present study, glomerular dynamics were examined by direct glomerular puncture during loop perfusion with Ringer solution at rates of 0 and 40 nl/min. With the increased loop flow, single nephron GFR (SNGFR) decreased by approximately 35%. Because directly measured PGC remained unchanged, this reduction in SNGFR was due to the falls in glomerular plasma flow rate and ultrafiltration coefficient, the former a consequence of increases in both afferent and efferent arteriolar resistances. By contrast, PGC values estimated by the stop-flow technique declined substantially with increased loop flow. These results indicate that tubuloglomerular feedback-induced regulation of GFR is mediated by changes in the vasomotor tone of preglomerular, glomerular, and postglomerular vessels. In view of the close anatomical contact between mesangial cells and these vessels, mesangial contractility may play a role as the single effector mechanism regulating the vasomotor tone of these vessels.
Authors:
I Ichikawa
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Kidney international. Supplement     Volume:  12     ISSN:  0098-6577     ISO Abbreviation:  Kidney Int. Suppl.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7508622     Medline TA:  Kidney Int Suppl     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  S109-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Glomerular Filtration Rate
Hemodynamics
Kidney Glomerulus / blood supply*,  physiology
Kidney Tubules / metabolism*
Kidney Tubules, Distal / metabolism*
Microcirculation
Rats
Rats, Inbred Strains
Sodium Chloride / metabolism*
Grant Support
ID/Acronym/Agency:
AM-19467/AM/NIADDK NIH HHS; AM-27853/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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