Document Detail

Hemodynamic and humoral conditions in stepwise reduction of pulmonary blood flow during venoarterial bypass in awake goats.
MedLine Citation:
PMID:  9360092     Owner:  NLM     Status:  MEDLINE    
The effects of reduced pulmonary arterial blood flow (PAF) during venoarterial bypass (VAB) on hemodynamic and humoral conditions were investigated in a series of experiments in a chronic animal model. A biventricular bypass system was installed in five adult goats weighing 49.8 +/- 1.1 kg. Two weeks later, the extracorporeal circuitry was changed to VAB without anesthesia. The PAF was reduced stepwise from 100% to 50, 25, 10, and 0% of total systemic flow. The mean aortic pressure and systemic vascular resistance decreased from 110 +/- 14 to 66 +/- 3 mmHg and from 1,288 +/- 77 to 740 +/- 73 dyne.sec/cm5, respectively, in proportion to the decrease in PAF from 100 to 0%. The prostaglandin E2 concentration increased from 1.5 +/- 0.6 to 8.8 +/- 0.6 pg/ml following the decrease in PAF from 100 to 0%. The renin-angiotensin system increased in proportion to the decrease in PAF. In contrast, the epinephrine and norepinephrine concentrations (60 +/- 10 and 227 +/- 80 pg/ml, respectively, at 100% PAF) did not change appreciably even at 10% PAF, but were markedly elevated to 335 +/- 117 and 2,088 +/- 1,503 pg/ml at 0% PAF. The antidiuretic hormone level similarly changed. In conclusion, decrease in PAF during VAB exerts significant effects on hemodynamics in a proportional manner and on vasoactive humoral factors in a diverse manner.
Y Takewa; E Tatsumi; Y Taenaka; K Eya; T Nakatani; T Nishimura; Y S Sohn; T Masuzawa; Y Wakisaka; M Nakamura; S Endo; H Takano; S Kitamura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  43     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  1998-01-15     Completed Date:  1998-01-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M494-9     Citation Subset:  IM    
Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
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MeSH Terms
Carbon Dioxide / blood
Catecholamines / blood
Extracorporeal Circulation* / adverse effects
Models, Cardiovascular
Oxygen / blood
Prostaglandins / blood
Pulmonary Circulation / physiology*
Renin-Angiotensin System / physiology
Reg. No./Substance:
0/Catecholamines; 0/Prostaglandins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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