Document Detail

Hemodynamic and hormonal responses to atrial distension in the ovine fetus.
MedLine Citation:
PMID:  7573228     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to evaluate the hemodynamic and endocrine responses to elevations of atrial pressure in fetal sheep.
STUDY DESIGN: By use of a randomized block design, 10 ovine fetuses underwent pulmonary artery constriction proximal to the ductus arteriosus with and without propranolol pretreatment.
RESULTS: Atrial pressure doubled (p < 0.05), whereas mean arterial pressure remained unchanged (p > 0.05), in response to pulmonary artery constriction in both groups. Atrial natriuretic peptide tripled (p < 0.01), arginine vasopressin tripled (p < 0.05), and plasma renin activity doubled (p < 0.05) in both the constriction and constriction plus propranolol groups. No changes in fetal hematocrit values were demonstrated in any group.
CONCLUSIONS: The fetal sheep responds to increased atrial pressure with not only increased levels of atrial natriuretic peptide but also with arginine vasopressin and plasma renin activity over time. These changes occur in spite of increases in both atrial pressure and atrial natriuretic peptide. We speculate that the fetal heart may participate in redistribution of cardiac output by releasing atrial natriuretic peptide and augmenting secretion of arginine vasopressin and plasma renin activity.
R K Jaekle; A U Sheikh; D D Berry; L Washburn; J C Rose
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  173     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-26     Completed Date:  1995-10-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  694-701     Citation Subset:  AIM; IM    
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MeSH Terms
Arginine Vasopressin / blood*
Atrial Function / physiology
Atrial Natriuretic Factor / blood*
Blood Pressure
Fetal Blood / metabolism
Fetal Heart / physiology*
Heart Atria / embryology
Propranolol / pharmacology
Pulmonary Artery / embryology,  physiology
Renin / blood*
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 85637-73-6/Atrial Natriuretic Factor; 9Y8NXQ24VQ/Propranolol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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