| Hemodynamic, hormonal, and renal actions of adrenomedullin-2 in normal conscious sheep. | |
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MedLine Citation:
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PMID: 16410298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although blood pressure and heart rate effects have been reported for adrenomedullin 2 (AM-2), a new member of the calcitonin gene-related peptide superfamily, little information is available regarding other biological actions of systemically administered AM-2. Accordingly, we report for the first time the integrated hemodynamic, hormonal, and renal actions of the AM-2 in normal conscious sheep. AM-2 induced significant reductions in mean arterial pressure (P < 0.001). This was associated with dose-dependent rises in heart rate (P < 0.001) and cardiac output (P < 0.001) and dose-dependent falls in calculated total peripheral resistance (P < 0.001). Right atrial pressure was increased post infusion (P = 0.026), whereas hematocrit fell post infusion (P = 0.001). AM-2 also induced significant hormonal changes, particularly in the renin-angiotensin-aldosterone system where plasma renin activity was significantly activated (P < 0.001) associated with a dose-dependent rise in plasma aldosterone (P < 0.001). Plasma cAMP also rose in response to AM-2 (P < 0.001), as did circulating levels of the natriuretic peptides, particularly post infusion. In conclusion, iv infusions of AM-2 administered to normal conscious sheep induced significant hemodynamic actions including reduced mean arterial pressure and calculated total peripheral resistance and increased heart rate and cardiac output. Concurrently, AM-2 activated plasma cAMP, plasma renin activity, aldosterone, and the natriuretic peptides. With the exception of actions on aldosterone, these actions are similar to those previously reported for AM. Thus, AM-2 may be another important regulator of volume and pressure homeostasis and may play a role in the pathophysiology of heart disease. |
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Authors:
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Christopher J Charles; Miriam T Rademaker; A Mark Richards |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-12 |
Journal Detail:
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Title: Endocrinology Volume: 147 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-17 Completed Date: 2006-04-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 1871-7 Citation Subset: AIM; IM |
Affiliation:
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Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, New Zealand. chris.charles@chmeds.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin Animals Atrial Natriuretic Factor / blood Blood Pressure / drug effects Cardiac Output / drug effects Cyclic AMP / blood Female Heart Rate / drug effects Hemodynamics / drug effects* Kidney / drug effects*, innervation Natriuretic Peptide, Brain / blood Peptides / pharmacology* Renin / blood Sheep Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 114471-18-0/Natriuretic Peptide, Brain; 148498-78-6/Adrenomedullin; 60-92-4/Cyclic AMP; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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