| Hemodynamic and hormonal effects of renin inhibition in ovine heart failure. | |
| | |
MedLine Citation:
|
PMID: 2193544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of renin inhibition have not previously been documented in established heart failure (HF). Accordingly, we investigated the acute hemodynamic and hormonal effects of a renin inhibitor (EMD 52297) in an ovine model of HF induced by rapid ventricular pacing (LVP). In seven sheep, recordings were made for 1 h before, during a 2-h infusion of renin inhibitor (RI) or vehicle, and after each infusion on the 5th and 6th day after commencing LVP. The RI (20 micrograms.kg-1.min-1) or vehicle was given in random order. RI infusion induced a rapid fall in plasma renin activity (PRA) and angiotensin II, reaching a nadir at 20 min. The vasodilator response was characterized by a 16% fall in mean arterial pressure (MAP), which was related to the fall in PRA (r = 0.78, P less than 0.05). MAP and PRA remained suppressed throughout the infusion period, and both returned to preinfusion levels within 10 min of terminating infusions. Left atrial pressure and plasma aldosterone were not significantly altered, while renal function was preserved despite the fall in perfusion pressure. RI has significant hemodynamic actions in a model of established HF. |
| | |
Authors:
|
M A Fitzpatrick; M T Rademaker; C M Frampton; C J Charles; T G Yandle; E A Espiner; H Ikram |
Related Documents
:
|
9737094 - Hemodynamic response to vasopressin in dehydrated human subjects. 282074 - Relationship between the hypotensive and renin-stimulating actions of diuretic therapy ... 1244504 - Psychotherapeutic control of hypertension. 11087234 - Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hy... 15165874 - Flow pattern and shear stress distribution of distal end-to-side anastomoses. a compari... 998804 - Effects of angiotensin, vasopressin, and methoxamine on cardiac function and blood flow... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of physiology Volume: 258 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1990 Jun |
Date Detail:
|
Created Date: 1990-08-02 Completed Date: 1990-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: H1625-31 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Princess Margaret Hospital, Christchurch, New Zealand. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiac Output, Low / metabolism, physiopathology* Female Hemodynamics* Hormones / blood* Oligopeptides / pharmacology Renin / antagonists & inhibitors* Sheep |
| Chemical | |
Reg. No./Substance:
|
0/Hormones; 0/Oligopeptides; 129049-51-0/EMD 52297; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Superiority of salt restriction over diuretics in reducing renal hypertrophy and injury in uninephre...
Next Document: Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure...