Document Detail


Hemodynamic and hormonal effects of renin inhibition in ovine heart failure.
MedLine Citation:
PMID:  2193544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of renin inhibition have not previously been documented in established heart failure (HF). Accordingly, we investigated the acute hemodynamic and hormonal effects of a renin inhibitor (EMD 52297) in an ovine model of HF induced by rapid ventricular pacing (LVP). In seven sheep, recordings were made for 1 h before, during a 2-h infusion of renin inhibitor (RI) or vehicle, and after each infusion on the 5th and 6th day after commencing LVP. The RI (20 micrograms.kg-1.min-1) or vehicle was given in random order. RI infusion induced a rapid fall in plasma renin activity (PRA) and angiotensin II, reaching a nadir at 20 min. The vasodilator response was characterized by a 16% fall in mean arterial pressure (MAP), which was related to the fall in PRA (r = 0.78, P less than 0.05). MAP and PRA remained suppressed throughout the infusion period, and both returned to preinfusion levels within 10 min of terminating infusions. Left atrial pressure and plasma aldosterone were not significantly altered, while renal function was preserved despite the fall in perfusion pressure. RI has significant hemodynamic actions in a model of established HF.
Authors:
M A Fitzpatrick; M T Rademaker; C M Frampton; C J Charles; T G Yandle; E A Espiner; H Ikram
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-02     Completed Date:  1990-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1625-31     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Princess Margaret Hospital, Christchurch, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Output, Low / metabolism,  physiopathology*
Female
Hemodynamics*
Hormones / blood*
Oligopeptides / pharmacology
Renin / antagonists & inhibitors*
Sheep
Chemical
Reg. No./Substance:
0/Hormones; 0/Oligopeptides; 129049-51-0/EMD 52297; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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