Document Detail

Hemodynamic and hormonal actions of adrenomedullin.
MedLine Citation:
PMID:  15273827     Owner:  NLM     Status:  MEDLINE    
Adrenomedullin, a 52-amino acid residue peptide, has numerous biological actions which are of potential importance to cardiovascular homeostasis, growth and development of cardiovascular tissues and bone, prevention of infection, and regulation of body fluid and electrolyte balance. Studies in man using intravenous infusion of the peptide have demonstrated that, at plasma levels detected after myocardial infarction or in heart failure, adrenomedullin reduces arterial pressure, increases heart rate and cardiac output, and activates the sympathetic and renin-angiotensin systems but suppresses aldosterone. The thresholds for these responses differ, being lower under some experimental circumstances for arterial pressure than for the other biological effects. Adrenomedullin administration inhibits the pressor and aldosterone-stimulating action of angiotensin II in man. By contrast, the pressor effect of norepinephrine is little altered by concomitant adrenomedullin administration. Although in the absence of a safe, specific antagonist of the actions of endogenous adrenomedullin it is difficult to be certain about the physiological and pathophysiological importance of this peptide in man, current evidence suggests that it serves to protect against cardiovascular overload and injury. Hope has been expressed that adrenomedullin or an agonist specific for adrenomedullin receptors might find a place in the treatment of cardiovascular disorders.
M G Nicholls
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Publication Detail:
Type:  Journal Article; Review     Date:  2004-07-20
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  37     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-26     Completed Date:  2005-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1247-53     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
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MeSH Terms
Atrial Natriuretic Factor / drug effects
Blood Pressure / drug effects
Cardiotonic Agents / therapeutic use*
Endothelins / drug effects
Heart Failure / drug therapy*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*
Peptides / therapeutic use*
Reg. No./Substance:
0/Cardiotonic Agents; 0/Endothelins; 0/Peptides; 148498-78-6/Adrenomedullin; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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