| Hemodynamic and hormonal actions of adrenomedullin. | |
| | |
MedLine Citation:
|
PMID: 15273827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Adrenomedullin, a 52-amino acid residue peptide, has numerous biological actions which are of potential importance to cardiovascular homeostasis, growth and development of cardiovascular tissues and bone, prevention of infection, and regulation of body fluid and electrolyte balance. Studies in man using intravenous infusion of the peptide have demonstrated that, at plasma levels detected after myocardial infarction or in heart failure, adrenomedullin reduces arterial pressure, increases heart rate and cardiac output, and activates the sympathetic and renin-angiotensin systems but suppresses aldosterone. The thresholds for these responses differ, being lower under some experimental circumstances for arterial pressure than for the other biological effects. Adrenomedullin administration inhibits the pressor and aldosterone-stimulating action of angiotensin II in man. By contrast, the pressor effect of norepinephrine is little altered by concomitant adrenomedullin administration. Although in the absence of a safe, specific antagonist of the actions of endogenous adrenomedullin it is difficult to be certain about the physiological and pathophysiological importance of this peptide in man, current evidence suggests that it serves to protect against cardiovascular overload and injury. Hope has been expressed that adrenomedullin or an agonist specific for adrenomedullin receptors might find a place in the treatment of cardiovascular disorders. |
| | |
Authors:
|
M G Nicholls |
Related Documents
:
|
7117047 - Circadian variation of aldosterone urinary excretion in idiopathic hypertension. 19895757 - Aldosterone and cardiovascular risk. 271507 - The pathophysiology of renal hypertension. 6509787 - The blood pressure and metabolic effects of 19-nor-deoxycorticosterone and 19-nor-proge... 11384197 - Organ sites of lipopolysaccharide-induced nitric oxide production in the anesthetized rat. 3994447 - In vivo hemodynamics of prosthetic st. jude medical and ionescu-shiley heart valves ana... |
Publication Detail:
|
Type: Journal Article; Review Date: 2004-07-20 |
Journal Detail:
|
Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 37 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-07-26 Completed Date: 2005-04-04 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
|
Languages: eng Pagination: 1247-53 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. gary.nicholls@uaeu.ac.ae |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenomedullin Animals Atrial Natriuretic Factor / drug effects Blood Pressure / drug effects Cardiotonic Agents / therapeutic use* Endothelins / drug effects Heart Failure / drug therapy* Heart Rate / drug effects Hemodynamics / drug effects* Humans Hypertension / drug therapy* Hypopituitarism Peptides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Endothelins; 0/Peptides; 148498-78-6/Adrenomedullin; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atr...
Next Document: Enhanced expression of Ang-(1-7) during pregnancy.