Document Detail

Hemodynamic and histomorphometric characteristics of heart failure induced by aortic stenosis in the guinea pig: comparison of two constriction sizes.
MedLine Citation:
PMID:  19935898     Owner:  NLM     Status:  MEDLINE    
Heart failure induced by aortic stenosis in young guinea pigs could constitute an interesting model for pharmacology, but its natural history needs to be characterized. One hundred five guinea pigs (3-4 weeks old) underwent thoracic aortic banding with 12- (B12G) or 14-gauge (B14G) needles or similar sham operations (S12G, S14G). Animals alive at 7 d (S12G, n = 16; B12G, n = 28; S14G, n = 19; B14G, n = 27) were assessed at 60 or 120 d. At 60 d, compared with sham groups, left ventricular (LV) mass and wall thickness increased in operated groups, but LV systolic pressure and right ventricular (RV) wall thickness only increased in the B14G group. At 120 d, B12G animals still showed signs of compensated hypertrophy with LV and RV wall thickening (+8%, +21%) and LV dilation (+20%), whereas B14G animals showed signs of decompensation with LV end-diastolic pressure increase (+167%) and mean arterial pressure decrease (-28%) associated with LV and RV hypertrophy (+77%, + 51%) and greater increases of LV and RV wall thickening (+19%, + 57%), as well as LV dilation (+43%). A 12G stenosis results in compensated hypertrophy at 60 and 120 d; a 14G stenosis leads to compensated hypertrophy at 60 d and heart failure at 120 d.
Bruno Laviolle; Danielle Pape; Marie-Cl?mence Verdier; Audrey Lavenu; Eric Bellissant
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  87     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  908-14     Citation Subset:  IM    
Laboratoire de pharmacologie exp?rimentale et clinique, UPRES EA 3194 Groupe de recherche cardio-vasculaire, Facult? de m?decine, Universit? de Rennes 1, 2 Avenue du Pr. L?on Bernard, 35043 Rennes, France.
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MeSH Terms
Aortic Valve Stenosis / complications*,  mortality
Body Weight
Cardiomegaly / etiology,  physiopathology
Coronary Vessels / physiopathology*
Disease Models, Animal*
Disease Progression
Guinea Pigs
Heart Failure / etiology,  pathology,  physiopathology*
Kaplan-Meiers Estimate
Lung / pathology
Myocardium / pathology*
Organ Size
Random Allocation
Regional Blood Flow
Time Factors
Ventricular Remodeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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