Document Detail

Hemodynamic, hemorheologic, and hemocoagulative changes after treatment with picotamide in patients affected by peripheral arterial disease (PAD) of the lower limbs.
MedLine Citation:
PMID:  8129189     Owner:  NLM     Status:  MEDLINE    
Effects of picotamide on platelet activity and on some hemorheologic, coagulative, and hemodynamic parameters were investigated in a randomized, double-blind, placebo-controlled study for eighteen months. Twenty patients, average age 61.5 +/- 9.6 (SD) years, with peripheral arterial disease (PAD) at functional stage 2 of the Fontaine classification and with intermittent claudication for at least six months were studied. Ten patients received tablets of picotamide, 300 mg three times a day, and 10 subjects received three identical placebo tablets each day. Similar atherosclerotic disease risk factors were present in both groups. Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave.
M Neirotti; M Molaschi; M Ponzetto; C Macchione; L Poli; F Bonino; F Fabris
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  45     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-11     Completed Date:  1994-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Institute of Geriatric Medicine and Surgery, University of Turin, Italy.
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MeSH Terms
Arterial Occlusive Diseases / blood,  complications,  drug therapy*,  physiopathology
Blood Coagulation / drug effects
Blood Viscosity / drug effects
Double-Blind Method
Erythrocyte Deformability / drug effects
Fibrinogen / metabolism
Intermittent Claudication / complications*
Middle Aged
Peripheral Vascular Diseases / blood,  complications,  drug therapy*,  physiopathology
Phthalic Acids / pharmacology,  therapeutic use*
Platelet Aggregation Inhibitors / pharmacology,  therapeutic use*
beta-Thromboglobulin / analysis
Reg. No./Substance:
0/Phthalic Acids; 0/Platelet Aggregation Inhibitors; 0/beta-Thromboglobulin; 32828-81-2/picotamide; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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