| Hemodynamic, hemorheologic, and hemocoagulative changes after treatment with picotamide in patients affected by peripheral arterial disease (PAD) of the lower limbs. | |
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MedLine Citation:
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PMID: 8129189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of picotamide on platelet activity and on some hemorheologic, coagulative, and hemodynamic parameters were investigated in a randomized, double-blind, placebo-controlled study for eighteen months. Twenty patients, average age 61.5 +/- 9.6 (SD) years, with peripheral arterial disease (PAD) at functional stage 2 of the Fontaine classification and with intermittent claudication for at least six months were studied. Ten patients received tablets of picotamide, 300 mg three times a day, and 10 subjects received three identical placebo tablets each day. Similar atherosclerotic disease risk factors were present in both groups. Picotamide induced a significant decrease of plasma viscosity, fibrinogen, and beta-thromboglobulin and an increase of amplitude of the photoplethysmographic wave. |
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Authors:
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M Neirotti; M Molaschi; M Ponzetto; C Macchione; L Poli; F Bonino; F Fabris |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Angiology Volume: 45 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-04-11 Completed Date: 1994-04-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Institute of Geriatric Medicine and Surgery, University of Turin, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
/
blood,
complications,
drug therapy*,
physiopathology Blood Coagulation / drug effects Blood Viscosity / drug effects Double-Blind Method Erythrocyte Deformability / drug effects Fibrinogen / metabolism Hemorheology Humans Intermittent Claudication / complications* Male Middle Aged Peripheral Vascular Diseases / blood, complications, drug therapy*, physiopathology Photoplethysmography Phthalic Acids / pharmacology, therapeutic use* Platelet Aggregation Inhibitors / pharmacology, therapeutic use* beta-Thromboglobulin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Phthalic Acids; 0/Platelet Aggregation Inhibitors; 0/beta-Thromboglobulin; 32828-81-2/picotamide; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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