Document Detail

Hemodynamic factors and atheromatic plaque rupture in the coronary arteries: from vulnerable plaque to vulnerable coronary segment.
MedLine Citation:
PMID:  17429298     Owner:  NLM     Status:  MEDLINE    
Coronary plaque disruption with superimposed thrombosis is the underlying pathology in the acute coronary syndromes and sudden death. Coronary plaques are constantly stressed by a variety of mechanical and hemodynamic forces that may precipitate or 'trigger' disruption of vulnerable or, at extreme conditions, even stable plaques. This paper reviews the exciting new evidence on the hemodynamic factors that may play a role in this process and provides the rationale for the introduction of the concept of the vulnerable coronary segment in the study of acute coronary syndromes.
Demosthenes G Katritsis; John Pantos; Efstathios Efstathopoulos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Coronary artery disease     Volume:  18     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-12     Completed Date:  2007-07-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
Department of Cardiology, Athens Euroclinic, University of Athens, Athens, Greece.
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MeSH Terms
Coronary Artery Disease / physiopathology*
Coronary Thrombosis / physiopathology*
Risk Factors
Rupture, Spontaneous / physiopathology*

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