| Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment. | |
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MedLine Citation:
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PMID: 2574044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen patients with essential hypertension were treated with an alpha 1-adrenoceptor antagonist, terazosin (1 to 4 mg/day) for 12 months. To assess the mechanism of its antihypertensive effect, the hemodynamic and endocrinological responses to terazosin were determined before, 3, and 12 months after the administration of terazosin. Blood pressure significantly decreased within 2 weeks after the start of terazosin and its effect was sustained throughout the 12 month period. Pulse rate did not change except slight increase in the third month. The hemodynamic studies revealed that total peripheral resistance significantly decreased and cardiac output slightly increased, indicating that the antihypertensive effect of terazosin is mainly produced by its vasodilation. Blood volume and plasma volume did not change. Although plasma renin activity remained the same, plasma aldosterone significantly decreased in response to terazosin. Plasma noradrenaline increased in the third month, but returned to the baseline level in the twelfth month. Thus, terazosin monotherapy lowered blood pressure throughout one year without drug tolerance including volume expansion and/or accentuation of renin-angiotensin-aldosterone system or sympathetic function. |
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Authors:
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F Tomoda; M Takata; K Yoshida; K Yasumoto; M Mikawa; S Sasayama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 2 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-01-25 Completed Date: 1990-01-25 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 834-9 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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therapeutic use Adult Aged Female Hemodynamics / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Norepinephrine / blood Prazosin / analogs & derivatives*, therapeutic use Renin-Angiotensin System / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 19216-56-9/Prazosin; 51-41-2/Norepinephrine; 63590-64-7/Terazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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