| Hemodynamic and endocrine changes associated with hypotensive action of amosulalol in essential hypertension. | |
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MedLine Citation:
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PMID: 1383633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the hemodynamic and endocrine mechanisms of the hypotensive effect of amosulalol, an alpha- and beta-adrenoceptor antagonist, 19 patients with essential hypertension received amosulalol (20-80 mg/day; average 48.4 mg/day) for 16 weeks. Mean blood pressure (MBP) was significantly decreased (105 +/- 1 vs. 120 +/- 1 mm Hg, p less than 0.001), associated with a decrement in heart rate (HR). Although both cardiac index (CI, 3.68 +/- 0.09 vs. 3.91 +/- 0.09 L/min/m2, p less than 0.001) and total peripheral resistance index (TPRI, 2,271 +/- 78 vs. 2,441 +/- 79 dynes.s.cm-5.m2, p less than 0.001) were reduced, changes in TPRI positively correlated with those of MBP (r = 0.9155, p less than 0.001) but the change in CI did not (r = 0.3568, NS). Plasma renin activity (PRA, 0.55 +/- 0.09 vs. 0.95 +/- 0.14 ng/ml/h, p less than 0.05) and aldosterone concentration (4.6 +/- 0.4 vs. 8.6 +/- 0.5 ng/dl, p less than 0.001) were also decreased with amosulalol. Thus, the hypotensive effect of amosulalol may be due mainly to vasodilation by alpha 1-blocking action. In addition, this hypotensive effect may be facilitated by either beta-blocking action such as decreased cardiac output (CO), with suppression of reflex tachycardia or of the renin-angiotensin-aldosterone system. |
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Authors:
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K Ando; H Noda; E Ogata; T Fujita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 20 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-11-04 Completed Date: 1992-11-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7-10 Citation Subset: IM |
Affiliation:
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Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood* Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Cardiac Output / drug effects Ethanolamines / administration & dosage, pharmacology* Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Hypertension / drug therapy, physiopathology* Male Middle Aged Radioimmunoassay Renin / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Ethanolamines; 52-39-1/Aldosterone; 70958-86-0/amosulalol; EC 3.4.23.15/Renin |
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