Document Detail


Hemodynamic and electrocardiographic effects in man of a new nonionic contrast agent (iohexol): advantages over standard ionic agents.
MedLine Citation:
PMID:  6837464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iohexol is a new, nonionic contrast material that has been shown in animal studies to hold great promise as an agent for coronary arteriography and ventriculography with fewer adverse hemodynamic effects than standard ionic media. At present, it has not been studied systematically in man. Fifty patients referred for elective cardiac catheterization were randomized to receive either iohexol or meglumine sodium diatrizoate (Renografin-76). Both operator and patient were blinded as to which agent was being used. Hemodynamic variables measured were pulmonary artery wedge pressure and systemic blood pressure. In addition, the following electrocardiographic indexes were evaluated: S-T segment shifts, changes in Q-T interval, changes in T-wave amplitude, and changes in heart rate. These variables were measured after left ventriculography and after both left and right coronary arteriography. Both iohexol and sodium meglumine diatrizoate produced small transient elevations in pulmonary artery wedge pressure. Systemic hypotension occurred with both agents but was more profound and longer-lasting with sodium meglumine diatrizoate. Iohexol injection resulted in no electrocardiographic changes, whereas sodium meglumine diatrizoate produced marked Q-T prolongation, as well as changes in T-wave amplitude and heart rate. Iohexol was well tolerated by the patients, and radiographic opacification was good to excellent in all cases. Thus, iohexol produces fewer deleterious hemodynamic and electrocardiographic changes than sodium meglumine diatrizoate when studied in a typical adult population requiring diagnostic cardiac catheterization. This favorable preliminary experience in man has potential widespread importance because of the large number of patients undergoing angiographic procedures.
Authors:
G B Mancini; J N Bloomquist; V Bhargava; J B Stein; W Lew; R A Slutsky; R Shabetai; C B Higgins
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  51     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1218-22     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Contrast Media / pharmacology*
Coronary Angiography
Coronary Disease / physiopathology,  radiography
Diatrizoate Meglumine / diagnostic use,  pharmacology
Double-Blind Method
Electrocardiography
Heart / drug effects*
Heart Catheterization
Heart Valve Diseases / physiopathology,  radiography
Heart Ventricles / radiography
Hemodynamics / drug effects*
Humans
Iodobenzoates / pharmacology*
Iohexol
Middle Aged
Triiodobenzoic Acids / diagnostic use,  pharmacology*
Grant Support
ID/Acronym/Agency:
1K04HL00201/HL/NHLBI NIH HHS; HL-17682/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Iodobenzoates; 0/Triiodobenzoic Acids; 131-49-7/Diatrizoate Meglumine; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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