Document Detail


Hemodynamic effects of prolonged intravenous therapy with enoximone in patients with severe congestive heart failure.
MedLine Citation:
PMID:  2450249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic differences between bolus administration and constant intravenous infusion over a 48-h period with enoximone, a new positive inotropic/vasodilator agent, were evaluated. Twenty-four patients were studied, 15 patients in the bolus group (Group A) and nine patients in the constant infusion group (Group B). The overall hemodynamic results were similar in both groups. Cardiac output increased in Group A from 3.1 +/- 0.71 to 5.5 +/- 1.3 L/min and in Group B from 3.6 +/- 1.0 to 5.9 +/- 1.2 L/min. Significant decreases occurred in pulmonary capillary wedge pressure (30 +/- 7 to 20 +/- 8 mm Hg and 37 +/- 5 to 21 +/- 11 mm Hg) and systemic vascular resistance (2184 +/- 456 to 1300 +/- 305 dyn.s.cm-5 and 1752 +/- 415 to 1035 +/- 130 dyn.s.cm-5). Group A required repeat drug boluses every 3-5 h to maintain these hemodynamic effects. The terminal blood half-life of enoximone derived following the continuous infusion in Group B was 10.6 +/- 7.0 h. In conclusion, intravenous enoximone produces acute salutary hemodynamic effects in patients with severe congestive heart failure that can be sustained for at least 48 h by intermittent boluses or a continuous infusion.
Authors:
D R Ferry; G T Kennedy; R A O'Rourke; M H Crawford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  11     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7872.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiac Output / drug effects
Enoximone
Heart Failure / drug therapy*,  physiopathology
Hemodynamics / drug effects*
Humans
Imidazoles / administration & dosage*
Infusions, Intravenous
Male
Middle Aged
Pulmonary Wedge Pressure / drug effects
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
T32HL070350/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Imidazoles; 77671-31-9/Enoximone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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