Document Detail


Hemodynamic effects of phentolamine in valvular abnormalities.
MedLine Citation:
PMID:  742729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven patients with mitral insufficiency and seven patients with aortic insufficiency were studied by right and left heart catheterization. Hemodynamic observations were made during a control period and during the infusion of phentolamine. Significant declines in the pulmonary artery mean pressure, left ventricular end diastolic pressure, peripheral resistance, and arteriovenous oxygen difference were seen in both groups. The cardiac index increased significantly in the two groups. Phentolamine therapy produced favorable hemodynamic effects because of its vasodilating action as well as its positive inotropic effects.
Authors:
L Gould; C V Reddy; S G Kim; K C Oh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  29     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-04-26     Completed Date:  1979-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-906     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aortic Valve Insufficiency / drug therapy*
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Mitral Valve Insufficiency / drug therapy*
Oxygen Consumption / drug effects
Phentolamine / therapeutic use*
Chemical
Reg. No./Substance:
50-60-2/Phentolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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