Document Detail


Hemodynamic effects of pentobarbital therapy for intracranial hypertension.
MedLine Citation:
PMID:  6884049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Barbiturate therapy has been employed for reduction of increased intracranial pressure (ICP) after acute brain injury and also for cerebral resuscitation. However, this treatment may be complicated by hypotension with an adverse impact on survival. We, therefore, investigated the acute hemodynamic effects of pentobarbital (PB) when administered in loading doses of 4-7 mg/kg and maintenance doses of 1-4 mg/kg. After pentobarbital therapy, HR, mean arterial pressure (MAP), and rectal temperature were significantly reduced. Four episodes of hypotension and 6 episodes of oliguria were observed during the initial 12 h of therapy in close relationship to reduced cardiac output, stroke volume, and MAP. These abnormalities were corrected by infusion of colloid-containing fluids. We postulate that increases in venous capacitance, hypovolemia, and decreased barostatic reflexes, rather than depression of myocardial function, accounted for the hemodynamic abnormalities.
Authors:
S M Traeger; R J Henning; W Dobkin; S Giannotta; M H Weil; M Weiss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  11     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-701     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Brain Injuries / drug therapy
Cerebrovascular Circulation / drug effects
Hemodynamics / drug effects*
Humans
Intracranial Pressure / drug effects*
Middle Aged
Pentobarbital / pharmacology*,  therapeutic use
Grant Support
ID/Acronym/Agency:
R01 HL 23015/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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